Metallic solid supports modified with nucleic acids

Thomas J Meade (Inventor), Jon F. Kayyem (Inventor)

Research output: Patent


The present invention is directed to solid supports having metallic surfaces comprising blocking moieties and modified nucleic acids, which exhibit excellent characteristics in hybridization assays, in a stable, reproducible, rapid manner. In an additional aspect, the invention provides methods utilizing the solid supports to hybridize probe nucleic acid to target nucleic acid and methods for detecting the hybridization complex.
Original languageEnglish (US)
Patent number6265155
Filing date2/28/97
StatePublished - Jul 24 2001

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