Metastasis infiltration: An investigation of the postoperative brain-tumor interface

Bethwel Raore, Matthew Schniederjan, Roshan Prabhu, Daniel J. Brat, Hui Kuo Shu, Jeffrey J. Olson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Purpose: This study aims to evaluate brain infiltration of metastatic tumor cells past the main tumor resection margin to assess the biological basis for the use of stereotactic radiosurgery treatment of the tumor resection cavity and visualized resection edge or clinical target volume. Methods and Materials: Resection margin tissue was obtained after gross total resection of a small group of metastatic lesions from a variety of primary sources. The tissue at the border of the tumor and brain tissue was carefully oriented and processed to evaluate the presence of tumor cells within brain tissue and their distance from the resection margin. Results: Microscopic assessment of the radially oriented tissue samples showed no tumor cells infiltrating the surrounding brain tissue. Among the positive findings were reactive astrocytosis observed on the brain tissue immediately adjacent to the tumor resection bed margin. Conclusions: The lack of evidence of metastatic tumor cell infiltration into surrounding brain suggests the need to target only a narrow depth of the resection cavity margin to minimize normal tissue injury and prevent treatment size-dependent stereotactic radiosurgery complications.

Original languageEnglish (US)
Pages (from-to)1075-1080
Number of pages6
JournalInternational Journal of Radiation Oncology Biology Physics
Issue number4
StatePublished - Nov 15 2011


  • Metastasis infiltration
  • Postresection radiation
  • Resection cavity
  • Resection cavity radiation
  • Resection margin targeting

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation
  • Cancer Research


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