Metastatic chromophobe renal cell carcinoma in pleural fluid cytology: Review of literature and report of a case

Simone Davion; Stephen Rohan; Ritu Nayar; Peter Kulesza

doi:10.1002/dc.21671

Metastatic chromophobe renal cell carcinoma in pleural fluid cytology: Review of literature and report of a case

Simone Davion, Stephen Rohan, Ritu Nayar, Peter Kulesza^*

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

The majority of chromophobe renal cell carcinomas (CHRCC) are not aggressive, however, a subset are. The potential for metastasis makes recognition of CHRCC cells in cytologic preparations important for patient surveillance, management, and treatment. We report the detection of an aggressive form of CHRCC in pleural fluid cytology with histopathologic confirmation on subsequent pleural biopsy. Sarcomatoid portions of the original CHRCC, and the pleural metastasis, demonstrated loss of diffuse membranous staining with C-KIT.

Original language	English (US)
Pages (from-to)	826-829
Number of pages	4
Journal	Diagnostic cytopathology
Volume	40
Issue number	9
DOIs	https://doi.org/10.1002/dc.21671
State	Published - Sep 1 2012

Keywords

C-KIT
chromophobe
imatinib

ASJC Scopus subject areas

Pathology and Forensic Medicine
Histology

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abstract = "The majority of chromophobe renal cell carcinomas (CHRCC) are not aggressive, however, a subset are. The potential for metastasis makes recognition of CHRCC cells in cytologic preparations important for patient surveillance, management, and treatment. We report the detection of an aggressive form of CHRCC in pleural fluid cytology with histopathologic confirmation on subsequent pleural biopsy. Sarcomatoid portions of the original CHRCC, and the pleural metastasis, demonstrated loss of diffuse membranous staining with C-KIT.",

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AU - Nayar, Ritu

AU - Kulesza, Peter

PY - 2012/9/1

Y1 - 2012/9/1

N2 - The majority of chromophobe renal cell carcinomas (CHRCC) are not aggressive, however, a subset are. The potential for metastasis makes recognition of CHRCC cells in cytologic preparations important for patient surveillance, management, and treatment. We report the detection of an aggressive form of CHRCC in pleural fluid cytology with histopathologic confirmation on subsequent pleural biopsy. Sarcomatoid portions of the original CHRCC, and the pleural metastasis, demonstrated loss of diffuse membranous staining with C-KIT.

AB - The majority of chromophobe renal cell carcinomas (CHRCC) are not aggressive, however, a subset are. The potential for metastasis makes recognition of CHRCC cells in cytologic preparations important for patient surveillance, management, and treatment. We report the detection of an aggressive form of CHRCC in pleural fluid cytology with histopathologic confirmation on subsequent pleural biopsy. Sarcomatoid portions of the original CHRCC, and the pleural metastasis, demonstrated loss of diffuse membranous staining with C-KIT.

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KW - chromophobe

KW - imatinib

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Metastatic chromophobe renal cell carcinoma in pleural fluid cytology: Review of literature and report of a case

Abstract

Keywords

ASJC Scopus subject areas

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