Metastatic chromophobe renal cell carcinoma in pleural fluid cytology: Review of literature and report of a case

Simone Davion; Stephen Rohan; Ritu Nayar; Peter Kulesza

doi:10.1002/dc.21671

Metastatic chromophobe renal cell carcinoma in pleural fluid cytology: Review of literature and report of a case

Simone Davion, Stephen Rohan, Ritu Nayar, Peter Kulesza^*

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

The majority of chromophobe renal cell carcinomas (CHRCC) are not aggressive, however, a subset are. The potential for metastasis makes recognition of CHRCC cells in cytologic preparations important for patient surveillance, management, and treatment. We report the detection of an aggressive form of CHRCC in pleural fluid cytology with histopathologic confirmation on subsequent pleural biopsy. Sarcomatoid portions of the original CHRCC, and the pleural metastasis, demonstrated loss of diffuse membranous staining with C-KIT.

Original language	English (US)
Pages (from-to)	826-829
Number of pages	4
Journal	Diagnostic cytopathology
Volume	40
Issue number	9
DOIs	https://doi.org/10.1002/dc.21671
State	Published - Sep 1 2012

Keywords

C-KIT
chromophobe
imatinib

ASJC Scopus subject areas

Pathology and Forensic Medicine
Histology

Access to Document

10.1002/dc.21671

Cite this

@article{88cd0e3b52254579abdfad91b7c6502e,

title = "Metastatic chromophobe renal cell carcinoma in pleural fluid cytology: Review of literature and report of a case",

abstract = "The majority of chromophobe renal cell carcinomas (CHRCC) are not aggressive, however, a subset are. The potential for metastasis makes recognition of CHRCC cells in cytologic preparations important for patient surveillance, management, and treatment. We report the detection of an aggressive form of CHRCC in pleural fluid cytology with histopathologic confirmation on subsequent pleural biopsy. Sarcomatoid portions of the original CHRCC, and the pleural metastasis, demonstrated loss of diffuse membranous staining with C-KIT.",

keywords = "C-KIT, chromophobe, imatinib",

author = "Simone Davion and Stephen Rohan and Ritu Nayar and Peter Kulesza",

year = "2012",

month = sep,

day = "1",

doi = "10.1002/dc.21671",

language = "English (US)",

volume = "40",

pages = "826--829",

journal = "Diagnostic Cytopathology",

issn = "8755-1039",

publisher = "Wiley-Liss Inc.",

number = "9",

}

TY - JOUR

T1 - Metastatic chromophobe renal cell carcinoma in pleural fluid cytology

T2 - Review of literature and report of a case

AU - Davion, Simone

AU - Rohan, Stephen

AU - Nayar, Ritu

AU - Kulesza, Peter

PY - 2012/9/1

Y1 - 2012/9/1

N2 - The majority of chromophobe renal cell carcinomas (CHRCC) are not aggressive, however, a subset are. The potential for metastasis makes recognition of CHRCC cells in cytologic preparations important for patient surveillance, management, and treatment. We report the detection of an aggressive form of CHRCC in pleural fluid cytology with histopathologic confirmation on subsequent pleural biopsy. Sarcomatoid portions of the original CHRCC, and the pleural metastasis, demonstrated loss of diffuse membranous staining with C-KIT.

AB - The majority of chromophobe renal cell carcinomas (CHRCC) are not aggressive, however, a subset are. The potential for metastasis makes recognition of CHRCC cells in cytologic preparations important for patient surveillance, management, and treatment. We report the detection of an aggressive form of CHRCC in pleural fluid cytology with histopathologic confirmation on subsequent pleural biopsy. Sarcomatoid portions of the original CHRCC, and the pleural metastasis, demonstrated loss of diffuse membranous staining with C-KIT.

KW - C-KIT

KW - chromophobe

KW - imatinib

UR - http://www.scopus.com/inward/record.url?scp=84865078819&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865078819&partnerID=8YFLogxK

U2 - 10.1002/dc.21671

DO - 10.1002/dc.21671

M3 - Review article

C2 - 21472872

AN - SCOPUS:84865078819

VL - 40

SP - 826

EP - 829

JO - Diagnostic Cytopathology

JF - Diagnostic Cytopathology

SN - 8755-1039

IS - 9

ER -

Metastatic chromophobe renal cell carcinoma in pleural fluid cytology: Review of literature and report of a case

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this