Metastatic chromophobe renal cell carcinoma in pleural fluid cytology: Review of literature and report of a case

Simone Davion, Stephen Rohan, Ritu Nayar, Peter Kulesza*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

The majority of chromophobe renal cell carcinomas (CHRCC) are not aggressive, however, a subset are. The potential for metastasis makes recognition of CHRCC cells in cytologic preparations important for patient surveillance, management, and treatment. We report the detection of an aggressive form of CHRCC in pleural fluid cytology with histopathologic confirmation on subsequent pleural biopsy. Sarcomatoid portions of the original CHRCC, and the pleural metastasis, demonstrated loss of diffuse membranous staining with C-KIT.

Original languageEnglish (US)
Pages (from-to)826-829
Number of pages4
JournalDiagnostic cytopathology
Volume40
Issue number9
DOIs
StatePublished - Sep 1 2012

Keywords

  • C-KIT
  • chromophobe
  • imatinib

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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