Abstract
There is a global and urgent need for expanding our current therapeutical arsenal against leukemia in order to improve their actual cure rates and fight relapse. Targeting the reprogrammed, altered cancer metabolism is an emerging strategy which should profoundly affect cancer cells in their intimate and irrepressible needs and addictions for nutrients uptake and incorporation into the biomass during malignant proliferation. We present here how metformin, an anti-diabetic drug that has attracted a strong interest for its recently discovered anti-cancer properties, can be envisioned as a new adjuvant approach to treat leukemia. Metformin may have a double-edged sword effect (i) by acting on the organism to decrease hyperglycaemia and hyperinsulinemia in diabetic patients and (ii) at the cellular level, by inhibiting the mTORC1-cancer supporting pathway through AMPK-dependent and independent mechanisms.
Original language | English (US) |
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Pages (from-to) | 188-196 |
Number of pages | 9 |
Journal | Cancer Letters |
Volume | 346 |
Issue number | 2 |
DOIs | |
State | Published - May 1 2014 |
Funding
CR is recipient of a PhD fellowship from La Ligue Nationale Contre le Cancer. FB is supported by INCA (Grants 2010-219 and 2010-Adipôk) and the Fondation ARC pour la recherche sur le Cancer.
Keywords
- AMPK
- Acute leukemia
- Adjuvant chemotherapy
- MTOR
- Metformin
ASJC Scopus subject areas
- Oncology
- Cancer Research