@article{c61cd440aaea4bb8a08f3e41bebda12a,
title = "Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis",
abstract = "Urban particulate matter air pollution induces the release of pro-inflammatory cytokines including interleukin-6 (IL-6) from alveolar macrophages, resulting in an increase in thrombosis. Here, we report that metformin provides protection in this murine model. Treatment of mice with metformin or exposure of murine or human alveolar macrophages to metformin prevented the particulate matter-induced generation of complex III mitochondrial reactive oxygen species, which were necessary for the opening of calcium release-activated channels (CRAC) and release of IL-6. Targeted genetic deletion of electron transport or CRAC channels in alveolar macrophages in mice prevented particulate matter-induced acceleration of arterial thrombosis. These findings suggest metformin as a potential therapy to prevent some of the premature deaths attributable to air pollution exposure worldwide.",
author = "Saul Soberanes and Misharin, {Alexander V} and Amit Jairaman and Luisa Morales-Nebreda and McQuattie-Pimentel, {Alexandra C} and Takugo Cho and Hamanaka, {Robert B} and Meliton, {Angelo Y} and Reyfman, {Paul A} and Walter, {James M} and Ching-I Chen and Monica Chi and Stephen Chiu and Gonzalez-Gonzalez, {Francisco J} and Matthew Antalek and Hiam Abdala-Valencia and Chiarella, {Sergio E} and Sun, {Kaitlyn A} and Woods, {Parker S} and Ghio, {Andrew J} and Manu Jain and Harris Perlman and Ridge, {Karen M} and Morimoto, {Richard I} and Sznajder, {Jacob I} and Balch, {William E} and Bhorade, {Sangeeta M} and Ankit Bharat and Murali Prakriya and Chandel, {Navdeep S} and Mutlu, {G{\"o}khan M} and Budinger, {G R Scott}",
note = "Copyright {\textcopyright} 2018 Elsevier Inc. All rights reserved.",
year = "2018",
month = oct,
day = "11",
doi = "10.1016/j.cmet.2018.09.019",
language = "English (US)",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
}