Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis

Saul Soberanes, Alexander V. Misharin, Amit Jairaman, Luisa Morales-Nebreda, Alexandra C. McQuattie-Pimentel, Takugo Cho, Robert B. Hamanaka, Angelo Y. Meliton, Paul A. Reyfman, James M. Walter, Ching I. Chen, Monica Chi, Stephen Chiu, Francisco J. Gonzalez-Gonzalez, Matthew Antalek, Hiam Abdala-Valencia, Sergio E. Chiarella, Kaitlyn A. Sun, Parker S. Woods, Andrew J. GhioManu Jain, Harris Perlman, Karen M. Ridge, Richard I. Morimoto, Jacob I. Sznajder, William E. Balch, Sangeeta M. Bhorade, Ankit Bharat, Murali Prakriya, Navdeep S. Chandel, Gökhan M. Mutlu*, G. R.Scott Budinger

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

67 Scopus citations


Air pollution exposure has been linked to a variety of poor health outcomes, including an increased risk of death attributable to ischemic cardiovascular events. Soberanes et al. find that metformin may hold promise as a therapy, as its capacity to act as a mitochondrial complex I inhibitor prevents accelerated thrombosis in a murine model of particulate-matter inhalation.

Original languageEnglish (US)
Pages (from-to)335-347.e5
JournalCell Metabolism
Issue number2
StatePublished - Feb 5 2019


  • air pollution
  • calcium channels
  • electron transport chain
  • mitochondria
  • proteostasis
  • reactive oxygen species
  • signaling
  • thrombosis

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology


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