Methadone: Applied pharmacology and use as adjunctive treatment in chronic pain

Randall Brown*, C. Kraus, M. Fleming, S. Reddy

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

90 Scopus citations


This article reviews the unique pharmacological properties of methadone and outlines its appropriate clinical application, with focus upon its use in the treatment of chronic pain. Although methadone is most widely known for its use in the treatment of opioid dependence, methadone also provides effective analgesia. Patients who experience inadequate pain relief or intolerable side effects with other opioids or who suffer from neuropathic pain may benefit from a transition to methadone as their analgesic agent. Adverse effects, particularly respiratory depression and death, make a fundamental knowledge of methadone's pharmacological properties essential to the provider considering methadone as analgesic therapy for a patient with chronic pain.

Original languageEnglish (US)
Pages (from-to)654-659
Number of pages6
JournalPostgraduate Medical Journal
Issue number949
StatePublished - Nov 2004

ASJC Scopus subject areas

  • General Medicine


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