Methods to study mechanisms underlying altered hepatic drug elimination during pregnancy

Hyunyoung Jeong*, Catherine S. Stika

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Hepatic drug metabolism is a major route of drug elimination, mediated by multiple drug-metabolizing enzymes. Any changes in the rate and extent of hepatic drug metabolism can lead to altered drug efficacy or toxicity. Accumulating clinical evidence indicates that pregnancy is accompanied by changes in hepatic drug metabolism. In this article, we discuss in vitro and in vivo tools used to study the mechanisms underlying the altered drug metabolism during pregnancy, focusing on primary hepatocyte culture, transgenic animal models, and use of probe drugs to assess change in enzymatic activity. The information obtained from these studies has enabled prediction of clinical PK changes for a given drug in pregnant women.

Original languageEnglish (US)
Article number151228
JournalSeminars in Perinatology
Volume44
Issue number3
DOIs
StatePublished - Apr 2020

Keywords

  • Hepatic drug metabolism
  • Hepatocytes
  • Pregnancy
  • Transgenic mice

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'Methods to study mechanisms underlying altered hepatic drug elimination during pregnancy'. Together they form a unique fingerprint.

Cite this