TY - JOUR
T1 - Methotrexate Hepatotoxicity in Psoriasis
T2 - Consideration of Liver Biopsies at Regular Intervals
AU - Robinson, June K.
AU - Baughman, Richard D.
AU - Auerbach, Robert
AU - Cimis, Robert J.
PY - 1980/4
Y1 - 1980/4
N2 - Fibrosis of the liver developed to a degree that contraindicated further treatment with methotrexate in 11 of 43 patients who had been receiving maintenance therapy with methotrexate for psoriasis. Liver biopsy had been performed prior to initiation of methotrexate therapy and was repeated at 12- to 18-month intervals. In this retrospective study, age of the patient and duration of therapy have been found to be significant factors in those patients receiving only the weekly oral dosage schedule. Yearly biopsies of the liver are recommended for patients who receive methotrexate throughout their courses of therapy.
AB - Fibrosis of the liver developed to a degree that contraindicated further treatment with methotrexate in 11 of 43 patients who had been receiving maintenance therapy with methotrexate for psoriasis. Liver biopsy had been performed prior to initiation of methotrexate therapy and was repeated at 12- to 18-month intervals. In this retrospective study, age of the patient and duration of therapy have been found to be significant factors in those patients receiving only the weekly oral dosage schedule. Yearly biopsies of the liver are recommended for patients who receive methotrexate throughout their courses of therapy.
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U2 - 10.1001/archderm.1980.01640280049016
DO - 10.1001/archderm.1980.01640280049016
M3 - Article
C2 - 7369769
AN - SCOPUS:0018906122
VL - 116
SP - 413
EP - 415
JO - A. M. A. archives of dermatology and syphilology
JF - A. M. A. archives of dermatology and syphilology
SN - 2168-6068
IS - 4
ER -