Methylome-wide association study of central adiposity implicate genes involved in immune and endocrine systems

Anne E. Justice*, Geetha Chittoor, Rahul Gondalia, Phillip E. Melton, Elise Lim, Megan L. Grove, Eric A. Whitsel, Ching Ti Liu, L. Adrienne Cupples, Lindsay Fernandez-Rhodes, Weihua Guan, Jan Bressler, Myriam Fornage, Eric Boerwinkle, Yun Li, Ellen Demerath, Nancy Heard-Costa, Dan Levy, James D. Stewart, Andrea BaccarelliLifang Hou, Karen Conneely, Trevor Mori, Lawrence J. Beilin, Rae Chi Huang, Penny Gordon-Larsen, Annie Green Howard, Kari E. North

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

We conducted a methylome-wide association study to examine associations between DNA methylation in whole blood and central adiposity and body fat distribution, measured as waist circumference, waist-to-hip ratio, and waist-to-height ratio adjusted for body mass index, in 2684 African American adults in the Atherosclerosis Risk in Communities study. We validated significantly associated Cytosine-phosphate-Guanine methylation sites (CpGs) among adults using the Women’s Health Initiative and Framingham Heart Study participants (combined N=5743) and generalized associations in adolescents from The Raine Study (N=820). We identified 11 CpGs that were robustly associated with one or more central adiposity trait in adults and 2 in adolescents, including CpG site associations near TXNIP, ADCY7, SREBF1, and RAP1GAP2 that had not previously been associated with obesity-related traits.

Original languageEnglish (US)
JournalUnknown Journal
DOIs
StatePublished - Sep 12 2019

Keywords

  • Body fat distribution
  • Central adiposity
  • DNA methylation
  • Methylome-wide association study

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • Immunology and Microbiology(all)
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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