TY - JOUR
T1 - Metoprolol CR/XL in patients with heart failure
T2 - A pilot study examining the tolerability, safety, and effect on left ventricular ejection fraction
AU - Goldstein, S.
AU - Kennedy, H. L.
AU - Hall, C.
AU - Anderson, J. L.
AU - Gheorghiade, M.
AU - Gottlieb, S.
AU - Jessup, M.
AU - Karlsberg, R. P.
AU - Friday, G.
AU - Haskell, L.
PY - 1999
Y1 - 1999
N2 - Background: This study was designed to investigate the tolerability, safety, and effect on left ventricular function of a new long-acting preparation of metoprolol, metoprolol succinate (CR/XL). Methods and Results: Sixty patients were randomly assigned with a 2:1 ratio, drug versus placebo, administered with a gradually increasing dose of 12.5 to 150 mg of blinded medication during an 8-week period and continued for 6 months. The average peak dose achieved was 99 mg and 132 mg in the metoprolol succinate and placebo groups, respectively. The drug was well tolerated and there was no significant difference in drug withdrawals, New York Heart Association class, or quality of life assessment. The increase in left ventricular ejection fraction measure at baseline and 6 months measured by radioisotopic ventriculography was greater in the metoprolol succinate group (27.5% to 36.3%) than in the placebo group (26% to 27.9%) (P < .015). Examination of serial Holter electrocardiographic recordings indicate that metoprolol succinate therapy was associated with a significant (P < .05) decrease in total ventricular ectopy at 8 weeks of therapy and a decrease in ventricular couplets and nonsustained ventricular tachycardia at 8 through 26 weeks of therapy. No changes were observed in plasma norepinephrine during therapy except a transitory significant (P < .05) increase in N terminal proatrial natriuretic factor at 8 weeks in the metoprolol succinate group. Conclusions: This study indicates that treatment with metoprolol succinate for a 6-month period is safe and well tolerated and is associated with an increase in left ventricular election fraction and a decrease in ventricular ectopic beats.
AB - Background: This study was designed to investigate the tolerability, safety, and effect on left ventricular function of a new long-acting preparation of metoprolol, metoprolol succinate (CR/XL). Methods and Results: Sixty patients were randomly assigned with a 2:1 ratio, drug versus placebo, administered with a gradually increasing dose of 12.5 to 150 mg of blinded medication during an 8-week period and continued for 6 months. The average peak dose achieved was 99 mg and 132 mg in the metoprolol succinate and placebo groups, respectively. The drug was well tolerated and there was no significant difference in drug withdrawals, New York Heart Association class, or quality of life assessment. The increase in left ventricular ejection fraction measure at baseline and 6 months measured by radioisotopic ventriculography was greater in the metoprolol succinate group (27.5% to 36.3%) than in the placebo group (26% to 27.9%) (P < .015). Examination of serial Holter electrocardiographic recordings indicate that metoprolol succinate therapy was associated with a significant (P < .05) decrease in total ventricular ectopy at 8 weeks of therapy and a decrease in ventricular couplets and nonsustained ventricular tachycardia at 8 through 26 weeks of therapy. No changes were observed in plasma norepinephrine during therapy except a transitory significant (P < .05) increase in N terminal proatrial natriuretic factor at 8 weeks in the metoprolol succinate group. Conclusions: This study indicates that treatment with metoprolol succinate for a 6-month period is safe and well tolerated and is associated with an increase in left ventricular election fraction and a decrease in ventricular ectopic beats.
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U2 - 10.1016/S0002-8703(99)70083-9
DO - 10.1016/S0002-8703(99)70083-9
M3 - Article
C2 - 10577448
AN - SCOPUS:0032757563
SN - 0002-8703
VL - 138
SP - 1158
EP - 1165
JO - American heart journal
JF - American heart journal
IS - 6 I
ER -