Mfd, the bacterial transcription repair coupling factor: Translocation, repair and termination

Jeffrey Roberts; Joo Seop Park

doi:10.1016/j.mib.2004.02.014

Mfd, the bacterial transcription repair coupling factor: Translocation, repair and termination

Jeffrey Roberts^*, Joo Seop Park

^*Corresponding author for this work

Medicine, Nephrology Division

Research output: Contribution to journal › Review article › peer-review

74 Scopus citations

Abstract

Mfd is a widely conserved bacterial protein that couples DNA repair with transcription. Mfd recognizes RNA polymerase stalled at a non-coding template site of DNA damage, disrupts the transcription complex to release the transcript and enzyme, and recruits the DNA excision repair machinery to the site. The mechanism of RNA release has been illuminated by the discovery that Mfd causes forward translocation of RNA polymerase, using an ATP-dependent motor that is highly homologous to that of the Holliday branch migration protein RecG.

Original language	English (US)
Pages (from-to)	120-125
Number of pages	6
Journal	Current Opinion in Microbiology
Volume	7
Issue number	2
DOIs	https://doi.org/10.1016/j.mib.2004.02.014
State	Published - Apr 2004

Keywords

Mfd
Mutation frequency decline
RNA polymerase
RNAP
TRCF
Transcription repair coupling factor

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases
Microbiology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.mib.2004.02.014

Cite this

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abstract = "Mfd is a widely conserved bacterial protein that couples DNA repair with transcription. Mfd recognizes RNA polymerase stalled at a non-coding template site of DNA damage, disrupts the transcription complex to release the transcript and enzyme, and recruits the DNA excision repair machinery to the site. The mechanism of RNA release has been illuminated by the discovery that Mfd causes forward translocation of RNA polymerase, using an ATP-dependent motor that is highly homologous to that of the Holliday branch migration protein RecG.",

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N2 - Mfd is a widely conserved bacterial protein that couples DNA repair with transcription. Mfd recognizes RNA polymerase stalled at a non-coding template site of DNA damage, disrupts the transcription complex to release the transcript and enzyme, and recruits the DNA excision repair machinery to the site. The mechanism of RNA release has been illuminated by the discovery that Mfd causes forward translocation of RNA polymerase, using an ATP-dependent motor that is highly homologous to that of the Holliday branch migration protein RecG.

AB - Mfd is a widely conserved bacterial protein that couples DNA repair with transcription. Mfd recognizes RNA polymerase stalled at a non-coding template site of DNA damage, disrupts the transcription complex to release the transcript and enzyme, and recruits the DNA excision repair machinery to the site. The mechanism of RNA release has been illuminated by the discovery that Mfd causes forward translocation of RNA polymerase, using an ATP-dependent motor that is highly homologous to that of the Holliday branch migration protein RecG.

KW - Mfd

KW - Mutation frequency decline

KW - RNA polymerase

KW - RNAP

KW - TRCF

KW - Transcription repair coupling factor

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Mfd, the bacterial transcription repair coupling factor: Translocation, repair and termination

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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