MIC2 analysis of small cell carcinoma

J. A. Lumadue, F. B. Askin, E. J. Perlman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


Small cell carcinomas (SCCs) and peripheral neuroectodermal tumors (PNETs) are two distinct neoplasms that show considerable histologic, immunohistochemical, and clinical overlap, but differ in their therapies and prognoses. In an attempt to further diagnostically distinguish the two, 33 SSCs were analyzed from both pulmonary and extrapulmonary sites for the MIC2 gene product, a cell surface antigen strongly and reliably expressed in PNETs and Ewing's sarcoma (ES). Two of the 33 SCCs stained positively, but the staining was less intense than that seen with PNET and ES. The remaining 31 tumors did not stain. These data indicate that, in combination with a panel of immunohistochemical stains, analysis of neuroendocrine tumors for MIC2 expression may be useful in distinguishing between small cell carcinomas of both pulmonary and extrapulmonary origins and soft tissue PNETs.

Original languageEnglish (US)
Pages (from-to)692-694
Number of pages3
JournalAmerican journal of clinical pathology
Issue number5
StatePublished - 1994


  • 12E7
  • Ewing's sarcoma
  • HBA71
  • MIC2
  • Peripheral neuroectodermal tumor
  • Small cell carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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