Mice that "conditionally" lack basophils, AT LAST

Booki Min*

*Corresponding author for this work

Research output: Contribution to journalComment/debatepeer-review


Basophils are the least abundant granulocytes found in the circulation. Until recently, their functions were poorly understood. In the past few years, the list of basophil functions in the context of immunity has dramatically increased. Thus, the need for basophil-deficient animal models to confirm these findings is imperative. In this issue of the JCI, Wada and colleagues introduce the first mouse model in which basophils are conditionally ablated in vivo. Using this model, they then uncover a nonredundant role for basophils in acquired immunity against tick infection.

Original languageEnglish (US)
Pages (from-to)2648-2651
Number of pages4
JournalJournal of Clinical Investigation
Issue number8
StatePublished - Aug 2 2010
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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