Micelle-enabled self-assembly of porous and monolithic carbon membranes for bioelectronic interfaces

Yin Fang*, Aleksander Prominski, Menahem Y. Rotenberg, Lingyuan Meng, Héctor Acarón Ledesma, Yingying Lv, Jiping Yue, Erik Schaumann, Junyoung Jeong, Naomi Yamamoto, Yuanwen Jiang, Benayahu Elbaz, Wei Wei, Bozhi Tian

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Real-world bioelectronics applications, including drug delivery systems, biosensing and electrical modulation of tissues and organs, largely require biointerfaces at the macroscopic level. However, traditional macroscale bioelectronic electrodes usually exhibit invasive or power-inefficient architectures, inability to form uniform and subcellular interfaces, or faradaic reactions at electrode surfaces. Here, we develop a micelle-enabled self-assembly approach for a binder-free and carbon-based monolithic device, aimed at large-scale bioelectronic interfaces. The device incorporates a multi-scale porous material architecture, an interdigitated microelectrode layout and a supercapacitor-like performance. In cell training processes, we use the device to modulate the contraction rate of primary cardiomyocytes at the subcellular level to target frequency in vitro. We also achieve capacitive control of the electrophysiology in isolated hearts, retinal tissues and sciatic nerves, as well as bioelectronic cardiac sensing. Our results support the exploration of device platforms already used in energy research to identify new opportunities in bioelectronics.

Original languageEnglish (US)
Pages (from-to)206-213
Number of pages8
JournalNature nanotechnology
Volume16
Issue number2
DOIs
StatePublished - Feb 2021

ASJC Scopus subject areas

  • Bioengineering
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering
  • Materials Science(all)
  • Condensed Matter Physics
  • Electrical and Electronic Engineering

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