Microbody (Peroxisome) proliferation in mouse kidney induced by methyl clofenapate

J. K. Reddy*, T. P. Krishnakantha, M. S. Rao

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Methyl-2-[4-(p-chlorophenyl)-phenoxy]-2-methylpropionate (methyl clofenapate) a hypolipidemic compound, was administered in the diet (0.03%) for 2-5 weeks to male wild type (Cs a strain) mice. Electron microscopic examination of the kidneys revealed a significant increase in the number of single membrane limited organelles in cells of the P 1 , P 2 and P 3 segments of the proximal convoluted tubule. Catalase was localized in these organelles cytochemically by incubating tissue in alkaline 3,3'-diaminobenzidine medium; which enabled their identification as peroxisomes. There was no increase in lysosomes in the renal tubules of methyl clofenapate treated animals. It is not certain if the presence of large number of peroxisomes in the proximal tubular epithelium causes impairment of renal function.

Original languageEnglish (US)
Pages (from-to)295-306
Number of pages12
JournalVirchows Archiv B Cell Pathology
Volume17
Issue number1
DOIs
StatePublished - Dec 1 1975

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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