Abstract
Nafenopin (2-methyl-2[P-(1,2,3,4-tetrahydro-1 naphthyl) phenoxy]- propionic acid, a phenolic ether with hypolipidemic properties, when administered by gavage at 100 mg/kg b wt daily for 1 to 2 weeks, caused a significant increase in the number of microbody profiles and simultaneous increase in catalase activity in livers of male rats. The concentration of catalase protein and the rate of incorporation of H3-δ-aminolevulinic acid into catalase fraction, as determined by immunochemical methods were approximately twice that of controls. The microbody proliferation resulting from nafenopin treatment was comparable to that induced by CPIB.
Original language | English (US) |
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Pages (from-to) | 537-543 |
Number of pages | 7 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 52 |
Issue number | 2 |
DOIs | |
State | Published - May 15 1973 |
Funding
This work was supported by USPHS grants GM-15956 and CA-5680. used in this investigation were generously supplied by Dr. William CIBA pharmaceuticals, Summit, N. .I. (Nafenopin) and by Dr. J. Noble, Laboratories, New York, N. Y. (CPIB).
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology