Microbody proliferation in liver induced by nafenopin, a new hypolipidemic drug: Comparison with CPIB

Janardan Reddy; Donald Svoboda; Daniel Azarnoff

doi:10.1016/0006-291X(73)90745-6

Microbody proliferation in liver induced by nafenopin, a new hypolipidemic drug: Comparison with CPIB

Janardan Reddy^*, Donald Svoboda, Daniel Azarnoff

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Nafenopin (2-methyl-2[P-(1,2,3,4-tetrahydro-1 naphthyl) phenoxy]- propionic acid, a phenolic ether with hypolipidemic properties, when administered by gavage at 100 mg/kg b wt daily for 1 to 2 weeks, caused a significant increase in the number of microbody profiles and simultaneous increase in catalase activity in livers of male rats. The concentration of catalase protein and the rate of incorporation of H³-δ-aminolevulinic acid into catalase fraction, as determined by immunochemical methods were approximately twice that of controls. The microbody proliferation resulting from nafenopin treatment was comparable to that induced by CPIB.

Original language	English (US)
Pages (from-to)	537-543
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	52
Issue number	2
DOIs	https://doi.org/10.1016/0006-291X(73)90745-6
State	Published - May 15 1973

Funding

This work was supported by USPHS grants GM-15956 and CA-5680. used in this investigation were generously supplied by Dr. William CIBA pharmaceuticals, Summit, N. .I. (Nafenopin) and by Dr. J. Noble, Laboratories, New York, N. Y. (CPIB).

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/0006-291X(73)90745-6

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title = "Microbody proliferation in liver induced by nafenopin, a new hypolipidemic drug: Comparison with CPIB",

abstract = "Nafenopin (2-methyl-2[P-(1,2,3,4-tetrahydro-1 naphthyl) phenoxy]- propionic acid, a phenolic ether with hypolipidemic properties, when administered by gavage at 100 mg/kg b wt daily for 1 to 2 weeks, caused a significant increase in the number of microbody profiles and simultaneous increase in catalase activity in livers of male rats. The concentration of catalase protein and the rate of incorporation of H3-δ-aminolevulinic acid into catalase fraction, as determined by immunochemical methods were approximately twice that of controls. The microbody proliferation resulting from nafenopin treatment was comparable to that induced by CPIB.",

author = "Janardan Reddy and Donald Svoboda and Daniel Azarnoff",

note = "Funding Information: This work was supported by USPHS grants GM-15956 and CA-5680. used in this investigation were generously supplied by Dr. William CIBA pharmaceuticals, Summit, N. .I. (Nafenopin) and by Dr. J. Noble, Laboratories, New York, N. Y. (CPIB).",

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AU - Reddy, Janardan

AU - Svoboda, Donald

AU - Azarnoff, Daniel

N1 - Funding Information: This work was supported by USPHS grants GM-15956 and CA-5680. used in this investigation were generously supplied by Dr. William CIBA pharmaceuticals, Summit, N. .I. (Nafenopin) and by Dr. J. Noble, Laboratories, New York, N. Y. (CPIB).

PY - 1973/5/15

Y1 - 1973/5/15

N2 - Nafenopin (2-methyl-2[P-(1,2,3,4-tetrahydro-1 naphthyl) phenoxy]- propionic acid, a phenolic ether with hypolipidemic properties, when administered by gavage at 100 mg/kg b wt daily for 1 to 2 weeks, caused a significant increase in the number of microbody profiles and simultaneous increase in catalase activity in livers of male rats. The concentration of catalase protein and the rate of incorporation of H3-δ-aminolevulinic acid into catalase fraction, as determined by immunochemical methods were approximately twice that of controls. The microbody proliferation resulting from nafenopin treatment was comparable to that induced by CPIB.

AB - Nafenopin (2-methyl-2[P-(1,2,3,4-tetrahydro-1 naphthyl) phenoxy]- propionic acid, a phenolic ether with hypolipidemic properties, when administered by gavage at 100 mg/kg b wt daily for 1 to 2 weeks, caused a significant increase in the number of microbody profiles and simultaneous increase in catalase activity in livers of male rats. The concentration of catalase protein and the rate of incorporation of H3-δ-aminolevulinic acid into catalase fraction, as determined by immunochemical methods were approximately twice that of controls. The microbody proliferation resulting from nafenopin treatment was comparable to that induced by CPIB.

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Microbody proliferation in liver induced by nafenopin, a new hypolipidemic drug: Comparison with CPIB

Abstract

Funding

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