Microenvironmental factors that regulate mesenchymal stem cells: Lessons learned from the study of heterotopic ossification

Chen Kan, Lijun Chen, Yangyang Hu, Haimei Lu, Yuyun Li, John A. Kessler, Lixin Kan*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Bone marrow contains a non-hematopoietic, clonogenic, multipotent population of stromal cells that are later called mesenchymal stem cells (MSC). Similar cells that share many common features with MSC are also found in other organs, which are thought to contribute both to normal tissue regeneration and to pathological processes such as heterotopic ossification (HO), the formation of ectopic bone in soft tissue. Understanding the microenvironmental factors that regulate MSC in vivo is essential both for understanding the biology of the stem cells and for effective translational applications of MSC. Unfortunately, this important aspect has been largely underappreciated. This review tries to raise the attention and highlight this critical issue by updating the relevant literature along with discussions of the key issues in the area.

Original languageEnglish (US)
Pages (from-to)977-985
Number of pages9
JournalHistology and histopathology
Volume32
Issue number10
DOIs
StatePublished - 2017

Keywords

  • Heterotopic ossification (HO)
  • Mesenchymal stem cell (MSC)
  • Microenvironmental factors
  • Tissue regeneration

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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