Microfluidic fabrication of 6-methoxyethylamino numonafide-eluting magnetic microspheres

D. H. Kim*, T. Choy, S. Huang, R. M. Green, R. A. Omary, A. C. Larson

*Corresponding author for this work

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Recently, 6-methoxyethylamino numonafide (MEAN) exhibited potent inhibition of hepatocellular carcinoma (HCC) cell growth and less systemic toxicity than amonafide. MEAN may serve as an ideal candidate for the treatment of HCC; however, liver-directed, selective infusion methods may be critical to maximize the MEAN dose delivered to the targeted tumors. This study describes the microfluidic fabrication of MEAN-eluting ultrasmall superparamagnetic iron oxide (USPIO) nanocluster-containing alginate microspheres (MEAN-magnetic microspheres) intended for selective transcatheter delivery to HCC. The resulting drug delivery platform was mono-disperse, microsphere sizes were readily controlled based on channel flow rates during synthesis procedures, and drug release rates from the microspheres could be readily controlled with the introduction of USPIO nanoclusters. The MR relaxivity properties of the microspheres suggest the feasibility of in vivo imaging after administration, and these microspheres exhibited potent therapeutic effects significantly inhibiting cell growth inducing apoptosis in hepatoma cells.

Original languageEnglish (US)
Pages (from-to)742-750
Number of pages9
JournalActa Biomaterialia
Volume10
Issue number2
DOIs
StatePublished - Feb 2014

Keywords

  • Anticancer drug
  • Controlled drug release
  • Liver cancer
  • Magnetic microspheres
  • Microfluidics

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering
  • Molecular Biology

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