Microfocal angiography of the pulmonary vasculature

Anne V. Clough*, Steven T. Haworth, David L. Roerig, John H. Linehan, Christopher A. Dawson

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review

1 Scopus citations


X-ray microfocal angiography provides a means of assessing regional microvascular perfusion parameters using residue detection of vascular indicators. As an application of this methodology, we studied the effects of alveolar hypoxia, a pulmonary vasoconstrictor, on the pulmonary microcirculation to determine changes in regional blood mean transit time, volume and flow between control and hypoxic conditions. Video x-ray images of a dog lung were acquired as a bolus of radiopaque contrast medium passed through the lobar vasculature. X-ray time-absorbance curves were acquired from arterial and microvascular regions-of-interest during both control and hypoxic alveolar gas conditions. A mathematical model based on indicator-dilution theory applied to image residue curves was applied to the data to determine changes in microvascular perfusion parameters. Sensitivity of the model parameters to the model assumptions was analyzed. Generally, the model parameter describing regional microvascular volume, corresponding to area under the microvascular absorbance curve, was the most robust. The results of the model analysis applied to the experimental data suggest a significant decrease in microvascular volume with hypoxia. However, additional model assumptions concerning the flow kinematics within the capillary bed may be required for assessing changes in regional microvascular flow and mean transit time from image residue data.

Original languageEnglish (US)
Pages (from-to)33-42
Number of pages10
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 1998
EventMedical Imaging 1998: Physiology and Function from Multidimensional Images - San Diego, CA, United States
Duration: Feb 22 1998Feb 23 1998


  • Alveolar hypoxia
  • Blood flow
  • Blood volume
  • Mean transit time
  • X-ray

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Applied Mathematics
  • Electrical and Electronic Engineering
  • Computer Science Applications


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