Microinjection of morphine into nucleus reticularis paragigantocellularis of the rat suppresses spontaneous activity of nucleus raphe magnus neurons

Mary M. Heinricher; J. Peter Rosenfeld

doi:10.1016/0006-8993(83)90589-9

Microinjection of morphine into nucleus reticularis paragigantocellularis of the rat suppresses spontaneous activity of nucleus raphe magnus neurons

Mary M. Heinricher^*, J. Peter Rosenfeld

^*Corresponding author for this work

Psychology

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Microinjection of morphine into nucleus reticularis paragigantocellularis of anesthetized rats had differential effects on spontaneous firing of neurons in nucleus raphe magnus (NRM) depending upon the dose of morphine administered. Microinjection of 1 μg of morphine, a dose which has reliable antinociceptive effects in awake animals, had predominantly suppressive effects on NRM spontaneous firing. Microinjection of 0.35 μg of morphine, a dose which has small and unreliable antinociceptive effects in awake animals, had little effect on the activity of NRM cells.

Original language	English (US)
Pages (from-to)	382-386
Number of pages	5
Journal	Brain research
Volume	272
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(83)90589-9
State	Published - Aug 8 1983

Funding

Supportedin part by NIH NIMH GrantT 32-M16097.

Keywords

analgesia
microinjection
morphine
nucleus raphe magnus
nucleus reticularis paragigantocellularis
pain

ASJC Scopus subject areas

Clinical Neurology
Molecular Biology
General Neuroscience
Developmental Biology

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title = "Microinjection of morphine into nucleus reticularis paragigantocellularis of the rat suppresses spontaneous activity of nucleus raphe magnus neurons",

abstract = "Microinjection of morphine into nucleus reticularis paragigantocellularis of anesthetized rats had differential effects on spontaneous firing of neurons in nucleus raphe magnus (NRM) depending upon the dose of morphine administered. Microinjection of 1 μg of morphine, a dose which has reliable antinociceptive effects in awake animals, had predominantly suppressive effects on NRM spontaneous firing. Microinjection of 0.35 μg of morphine, a dose which has small and unreliable antinociceptive effects in awake animals, had little effect on the activity of NRM cells.",

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T1 - Microinjection of morphine into nucleus reticularis paragigantocellularis of the rat suppresses spontaneous activity of nucleus raphe magnus neurons

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AU - Peter Rosenfeld, J.

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N2 - Microinjection of morphine into nucleus reticularis paragigantocellularis of anesthetized rats had differential effects on spontaneous firing of neurons in nucleus raphe magnus (NRM) depending upon the dose of morphine administered. Microinjection of 1 μg of morphine, a dose which has reliable antinociceptive effects in awake animals, had predominantly suppressive effects on NRM spontaneous firing. Microinjection of 0.35 μg of morphine, a dose which has small and unreliable antinociceptive effects in awake animals, had little effect on the activity of NRM cells.

AB - Microinjection of morphine into nucleus reticularis paragigantocellularis of anesthetized rats had differential effects on spontaneous firing of neurons in nucleus raphe magnus (NRM) depending upon the dose of morphine administered. Microinjection of 1 μg of morphine, a dose which has reliable antinociceptive effects in awake animals, had predominantly suppressive effects on NRM spontaneous firing. Microinjection of 0.35 μg of morphine, a dose which has small and unreliable antinociceptive effects in awake animals, had little effect on the activity of NRM cells.

KW - analgesia

KW - microinjection

KW - morphine

KW - nucleus raphe magnus

KW - nucleus reticularis paragigantocellularis

KW - pain

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Microinjection of morphine into nucleus reticularis paragigantocellularis of the rat suppresses spontaneous activity of nucleus raphe magnus neurons

Abstract

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Keywords

ASJC Scopus subject areas

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