Microinjection of morphine into nucleus reticularis paragigantocellularis of the rat suppresses spontaneous activity of nucleus raphe magnus neurons

Mary M. Heinricher*, Joel P Rosenfeld

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Microinjection of morphine into nucleus reticularis paragigantocellularis of anesthetized rats had differential effects on spontaneous firing of neurons in nucleus raphe magnus (NRM) depending upon the dose of morphine administered. Microinjection of 1 μg of morphine, a dose which has reliable antinociceptive effects in awake animals, had predominantly suppressive effects on NRM spontaneous firing. Microinjection of 0.35 μg of morphine, a dose which has small and unreliable antinociceptive effects in awake animals, had little effect on the activity of NRM cells.

Original languageEnglish (US)
Pages (from-to)382-386
Number of pages5
JournalBrain research
Volume272
Issue number2
DOIs
StatePublished - Aug 8 1983

Keywords

  • analgesia
  • microinjection
  • morphine
  • nucleus raphe magnus
  • nucleus reticularis paragigantocellularis
  • pain

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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