Micropapillary pattern in lung adenocarcinoma: Aspect on 18F-fluorodeoxyglucose positron emission tomography/computed tomography imaging

John O. Prior, Roger Stupp, Michel Christodoulou, Igor Letovanec

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


We diagnosed a non-small cell lung carcinoma in a 49-year-old female patient with the histopathological diagnosis of stage IIIB mixed bronchioloalveolar and papillary adenocarcinoma with extensive micropapillary feature, which was not visualized on the preoperative multimodality imaging with positron emission tomography (PET) and computed tomography (CT). The micropapillary component characterized by a unique growth pattern with particular morphological features can be observed in all subtypes of lung adenocarcinoma. Micropapillary component is increasingly recognized as a distinct entity associated with higher aggressiveness. Even the most modern multimodality PET/CT imaging technology may fail to adequately visualize this important component with highly relevant prognostic implications. Thus, the pathologist needs to consciously look for a micropapillary component in the surgical specimen or in preoperative biopsies or cytology. This may have potential future treatment implications, as adjuvant or neoadjuvant chemotherapy may be of relevance, even in the early stages of the disease.

Original languageEnglish (US)
Pages (from-to)144-145
Number of pages2
JournalInteractive cardiovascular and thoracic surgery
Issue number1
StatePublished - Jan 2010


  • F-FDG
  • Micropapillary component
  • Non-small cell lung cancer
  • PET/CT
  • Positron emission tomography

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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