Microparticles and Fibrinolysis

Loris Vallier, Sylvie Cointe, Romaric Lacroix, Amandine Bonifay, Coralie Judicone, Françoise Dignat-George, Hau C. Kwaan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Microparticles (MPs) are submicronic vesicles which are formed by budding of the cellular membrane of virtually any cell type in response to cell activation or apoptosis. Both circulating MPs and MPs generated within tissues harbor molecules with a large repertoire of biological activities and transfer material to target cells. Depending on their cellular origin, the stimuli triggering their formation, or their localization, they may participate in the maintenance of organ or vascular homeostasis as well as inducing dysfunction. MPs have mostly been described as having procoagulant properties. However, the fact that some MP subsets are able to efficiently generate plasmin suggests that the role of MPs in hemostasis is more complex than initially thought. In this review, we summarize key findings showing that MPs provide a heterogeneous catalytic surface for plasmin generation, according to their cellular origin. We further address the specific features of the MP-dependent fibrinolytic system. Potential consequences of this MP-associated fibrinolytic activity in pathology are illustrated in cancer.

Original languageEnglish (US)
Article number02362
Pages (from-to)129-134
Number of pages6
JournalSeminars in thrombosis and hemostasis
Volume43
Issue number2
DOIs
StatePublished - Mar 1 2017

Keywords

  • cancer
  • extracellular vesicles
  • fibrinolysis
  • hemostasis
  • microparticles

ASJC Scopus subject areas

  • Hematology
  • Cardiology and Cardiovascular Medicine

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