MicroRNA-128 governs neuronal excitability and motor behavior in mice

Chan Lek Tan, Joshua L. Plotkin, Morten T. Venø, Melanie Von Schimmelmann, Philip Feinberg, Silas Mann, Annie Handler, Jørgen Kjems, D. James Surmeier, Dónal O'Carroll, Paul Greengard, Anne Schaefer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

162 Scopus citations

Abstract

The control of motor behavior in animals and humans requires constant adaptation of neuronal networks to signals of various types and strengths. We found that microRNA-128 (miR-128), which is expressed in adult neurons, regulates motor behavior by modulating neuronal signaling networks and excitability. miR-128 governs motor activity by suppressing the expression of various ion channels and signaling components of the extracellular signal-regulated kinase ERK2 network that regulate neuronal excitability. In mice, a reduction of miR-128 expression in postnatal neurons causes increased motor activity and fatal epilepsy. Overexpression of miR-128 attenuates neuronal responsiveness, suppresses motor activity, and alleviates motor abnormalities associated with Parkinson's-like disease and seizures in mice. These data suggest a therapeutic potential for miR-128 in the treatment of epilepsy and movement disorders.

Original languageEnglish (US)
Pages (from-to)1254-1258
Number of pages5
JournalScience
Volume342
Issue number6163
DOIs
StatePublished - Jan 1 2013

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'MicroRNA-128 governs neuronal excitability and motor behavior in mice'. Together they form a unique fingerprint.

Cite this