MicroRNA-30c targets cytoskeleton genes involved in breast cancer cell invasion

Jessica Bockhorn, Kathy Yee, Ya Fang Chang, Aleix Prat, Dezheng Huo, Chika Nwachukwu, Rachel Dalton, Simo Huang, Kaitlin E. Swanson, Charles M. Perou, Olufunmilayo I. Olopade, Michael F. Clarke, Geoffrey L. Greene*, Huiping Liu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

Metastasis remains a significant challenge in treating cancer. A better understanding of the molecular mechanisms underlying metastasis is needed to develop more effective treatments. Here, we show that human breast tumor biomarker miR-30c regulates invasion by targeting the cytoskeleton network genes encoding twinfilin 1 (TWF1) and vimentin (VIM). Both VIM and TWF1 have been shown to regulate epithelial-to-mesenchymal transition. Similar to TWF1, VIM also regulates F-actin formation, a key component of cellular transition to a more invasive mesenchymal phenotype. To further characterize the role of the TWF1 pathway in breast cancer, we found that IL-11 is an important target of TWF1 that regulates breast cancer cell invasion and STAT3 phosphorylation. The miR-30c-VIM/TWF1 signaling cascade is also associated with clinical outcome in breast cancer patients.

Original languageEnglish (US)
Pages (from-to)373-382
Number of pages10
JournalBreast Cancer Research and Treatment
Volume137
Issue number2
DOIs
StatePublished - Jan 2013

Keywords

  • Breast tumor invasion
  • IL-11
  • TWF1
  • VIM
  • miR-30c

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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