MicroRNA-503 targets FGF2 and VEGFA and inhibits tumor angiogenesis and growth

Bisheng Zhou, Ruihua Ma, Wenxia Si, Sisi Li, Yan Xu, Xin Tu, Qing Wang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

172 Scopus citations

Abstract

FGF2 and VEGFA are the two most potent angiogenic factors. Here we report that miR-503 can simultaneously down-regulate FGF2 and VEGFA. The expression of miR-503 is repressed in HCC cells and primary tumors due to a potential epigenetic mechanism. Overexpression of miR-503 reduced tumor angiogenesis in vitro and in vivo. We also found that miR-503 expression was down-regulated by hypoxia through HIF1α. These results identify a miRNA that targets both FGF2 and VEGFA in cancers, demonstrate the anti-angiogenesis role of miR-503 in tumorigenesis, and provide a novel mechanism for hypoxia-induced FGF2 and VEGFA through HIF1α-mediated inhibition of miR-503.

Original languageEnglish (US)
Pages (from-to)159-169
Number of pages11
JournalCancer Letters
Volume333
Issue number2
DOIs
StatePublished - Jun 10 2013

Keywords

  • Angiogenesis
  • FGF2
  • Methylation
  • MiR-503
  • VEGFA

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint

Dive into the research topics of 'MicroRNA-503 targets FGF2 and VEGFA and inhibits tumor angiogenesis and growth'. Together they form a unique fingerprint.

Cite this