MicroRNA: A new tool for biomedical risk assessment and target identification in human uterine leiomyomas

Jian Jun Wei*, Patricia Soteropoulos

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

MicroRNA (miRNA) expression is tissue specific or cell-type specific. miRNA signatures are useful tools for tumor classification and target gene identification. We and others found that uterine leiomyomas (ULMs) expressed a distinct miRNA signature. In addition, miRNA expression appears to be strongly associated with race and other biomedical factors, such as tumor sizes. Among the most highly dysregulated miRNAs, let-7 miRNAs seem to play a critical role in tumorigenesis of ULMs through negative regulation of some key target oncogenes, including high mobility group 2.

Original languageEnglish (US)
Pages (from-to)515-521
Number of pages7
JournalSeminars in reproductive medicine
Volume26
Issue number6
DOIs
StatePublished - Nov 1 2008

Keywords

  • Ethnicity
  • Expression
  • Leiomyoma
  • microRNA

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Reproductive Medicine
  • Endocrinology
  • Obstetrics and Gynecology
  • Physiology (medical)

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