MicroRNA: A new tool for biomedical risk assessment and target identification in human uterine leiomyomas

Jian Jun Wei; Patricia Soteropoulos

doi:10.1055/s-0028-1096131

MicroRNA: A new tool for biomedical risk assessment and target identification in human uterine leiomyomas

Jian Jun Wei^*, Patricia Soteropoulos

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

MicroRNA (miRNA) expression is tissue specific or cell-type specific. miRNA signatures are useful tools for tumor classification and target gene identification. We and others found that uterine leiomyomas (ULMs) expressed a distinct miRNA signature. In addition, miRNA expression appears to be strongly associated with race and other biomedical factors, such as tumor sizes. Among the most highly dysregulated miRNAs, let-7 miRNAs seem to play a critical role in tumorigenesis of ULMs through negative regulation of some key target oncogenes, including high mobility group 2.

Original language	English (US)
Pages (from-to)	515-521
Number of pages	7
Journal	Seminars in reproductive medicine
Volume	26
Issue number	6
DOIs	https://doi.org/10.1055/s-0028-1096131
State	Published - Nov 2008

Keywords

Ethnicity
Expression
Leiomyoma
microRNA

ASJC Scopus subject areas

Physiology (medical)
Endocrinology
Obstetrics and Gynecology
Endocrinology, Diabetes and Metabolism
Reproductive Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1055/s-0028-1096131

Cite this

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title = "MicroRNA: A new tool for biomedical risk assessment and target identification in human uterine leiomyomas",

abstract = "MicroRNA (miRNA) expression is tissue specific or cell-type specific. miRNA signatures are useful tools for tumor classification and target gene identification. We and others found that uterine leiomyomas (ULMs) expressed a distinct miRNA signature. In addition, miRNA expression appears to be strongly associated with race and other biomedical factors, such as tumor sizes. Among the most highly dysregulated miRNAs, let-7 miRNAs seem to play a critical role in tumorigenesis of ULMs through negative regulation of some key target oncogenes, including high mobility group 2.",

keywords = "Ethnicity, Expression, Leiomyoma, microRNA",

author = "Wei, {Jian Jun} and Patricia Soteropoulos",

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T1 - MicroRNA

T2 - A new tool for biomedical risk assessment and target identification in human uterine leiomyomas

AU - Wei, Jian Jun

AU - Soteropoulos, Patricia

PY - 2008/11

Y1 - 2008/11

N2 - MicroRNA (miRNA) expression is tissue specific or cell-type specific. miRNA signatures are useful tools for tumor classification and target gene identification. We and others found that uterine leiomyomas (ULMs) expressed a distinct miRNA signature. In addition, miRNA expression appears to be strongly associated with race and other biomedical factors, such as tumor sizes. Among the most highly dysregulated miRNAs, let-7 miRNAs seem to play a critical role in tumorigenesis of ULMs through negative regulation of some key target oncogenes, including high mobility group 2.

AB - MicroRNA (miRNA) expression is tissue specific or cell-type specific. miRNA signatures are useful tools for tumor classification and target gene identification. We and others found that uterine leiomyomas (ULMs) expressed a distinct miRNA signature. In addition, miRNA expression appears to be strongly associated with race and other biomedical factors, such as tumor sizes. Among the most highly dysregulated miRNAs, let-7 miRNAs seem to play a critical role in tumorigenesis of ULMs through negative regulation of some key target oncogenes, including high mobility group 2.

KW - Ethnicity

KW - Expression

KW - Leiomyoma

KW - microRNA

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JO - Seminars in reproductive medicine

JF - Seminars in reproductive medicine

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ER -

MicroRNA: A new tool for biomedical risk assessment and target identification in human uterine leiomyomas

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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