MicroRNA dysregulation in neuropsychiatric disorders and cognitive dysfunction

Bin Xu, Pei Ken Hsu, Maria Karayiorgou*, Joseph A. Gogos

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

62 Scopus citations

Abstract

MicroRNAs (miRNA), a class of non-coding RNAs, are emerging as important modulators of neuronal development, structure and function. A connection has been established between abnormalities in miRNA expression and miRNA-mediated gene regulation and psychiatric and neurodevelopmental disorders as well as cognitive dysfunction. Establishment of this connection has been driven by progress in elucidating the genetic etiology of these phenotypes and has provided a context to interpret additional supporting evidence accumulating from parallel expression profiling studies in brains and peripheral blood of patients. Here we review relevant evidence that supports this connection and explore possible mechanisms that underlie the contribution of individual miRNAs and miRNA-related pathways to the pathogenesis and pathophysiology of these complex clinical phenotypes. The existing evidence provides useful hypotheses for further investigation as well as important clues for identifying novel therapeutic targets.

Original languageEnglish (US)
Pages (from-to)291-301
Number of pages11
JournalNeurobiology of Disease
Volume46
Issue number2
DOIs
StatePublished - May 1 2012

Keywords

  • 22q11.2
  • Autism
  • Cognitive dysfunction
  • Intellectual disability
  • MicroRNA
  • Psychiatric disorder
  • Risk gene
  • Schizophrenia

ASJC Scopus subject areas

  • Neurology

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