MicroRNA expression profiling identifies decreased expression of miR-205 in inflammatory breast cancer

Lei Huo*, Yan Wang, Yun Gong, Savitri Krishnamurthy, Jing Wang, Lixia Diao, Chang Gong Liu, Xiuping Liu, Feng Lin, William F. Symmans, Wei Wei, Xinna Zhang, Li Sun, Ricardo H. Alvarez, Naoto T. Ueno, Tamer M. Fouad, Kenichi Harano, Bisrat G. Debeb, Yun Wu, James ReubenMassimo Cristofanilli, Zhuang Zuo

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Inflammatory breast cancer is the most aggressive form of breast cancer. Identifying new biomarkers to be used as therapeutic targets is in urgent need. Messenger RNA expression profiling studies have indicated that inflammatory breast cancer is a transcriptionally heterogeneous disease, and specific molecular targets for inflammatory breast cancer have not been well established. We performed microRNA expression profiling in inflammatory breast cancer in comparison with locally advanced noninflammatory breast cancer in this study. Although many microRNAs were differentially expressed between normal breast tissue and tumor tissue, most of them did not show differential expression between inflammatory and noninflammatory tumor samples. However, by microarray analysis, quantitative reverse transcription PCR, and in situ hybridization, we showed that microRNA-205 expression was decreased not only in tumor compared with normal breast tissue, but also in inflammatory breast cancer compared with noninflammatory breast cancer. Lower expression of microRNA-205 correlated with worse distant metastasis-free survival and overall survival in our cohort. A small-scale immunohistochemistry analysis showed coexistence of decreased microRNA-205 expression and decreased E-cadherin expression in some ductal tumors. MicroRNA-205 may serve as a therapeutic target in advanced breast cancer including inflammatory breast cancer.

Original languageEnglish (US)
Pages (from-to)330-346
Number of pages17
JournalModern Pathology
Issue number4
StatePublished - Apr 1 2016

ASJC Scopus subject areas

  • General Medicine


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