MicroRNA function in Drosophila melanogaster

Richard W. Carthew*, Pamela Agbu, Ritika Giri

*Corresponding author for this work

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

Over the last decade, microRNAs have emerged as critical regulators in the expression and function of animal genomes. This review article discusses the relationship between microRNA-mediated regulation and the biology of the fruit fly Drosophila melanogaster. We focus on the roles that microRNAs play in tissue growth, germ cell development, hormone action, and the development and activity of the central nervous system. We also discuss the ways in which microRNAs affect robustness. Many gene regulatory networks are robust; they are relatively insensitive to the precise values of reaction constants and concentrations of molecules acting within the networks. MicroRNAs involved in robustness appear to be nonessential under uniform conditions used in conventional laboratory experiments. However, the robust functions of microRNAs can be revealed when environmental or genetic variation otherwise has an impact on developmental outcomes.

Original languageEnglish (US)
Pages (from-to)29-37
Number of pages9
JournalSeminars in Cell and Developmental Biology
Volume65
DOIs
StatePublished - May 2017

Keywords

  • Drosophila
  • MiRNAs
  • MicroRNAs

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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