Abstract
Over the last decade, microRNAs have emerged as critical regulators in the expression and function of animal genomes. This review article discusses the relationship between microRNA-mediated regulation and the biology of the fruit fly Drosophila melanogaster. We focus on the roles that microRNAs play in tissue growth, germ cell development, hormone action, and the development and activity of the central nervous system. We also discuss the ways in which microRNAs affect robustness. Many gene regulatory networks are robust; they are relatively insensitive to the precise values of reaction constants and concentrations of molecules acting within the networks. MicroRNAs involved in robustness appear to be nonessential under uniform conditions used in conventional laboratory experiments. However, the robust functions of microRNAs can be revealed when environmental or genetic variation otherwise has an impact on developmental outcomes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 29-37 |
| Number of pages | 9 |
| Journal | Seminars in Cell and Developmental Biology |
| Volume | 65 |
| DOIs | |
| State | Published - May 2017 |
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Keywords
- Drosophila
- MiRNAs
- MicroRNAs
ASJC Scopus subject areas
- Developmental Biology
- Cell Biology
Cite this
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MicroRNA function in Drosophila melanogaster. / Carthew, Richard W.; Agbu, Pamela; Giri, Ritika.
In: Seminars in Cell and Developmental Biology, Vol. 65, 05.2017, p. 29-37.Research output: Contribution to journal › Review article
TY - JOUR
T1 - MicroRNA function in Drosophila melanogaster
AU - Carthew, Richard W.
AU - Agbu, Pamela
AU - Giri, Ritika
PY - 2017/5
Y1 - 2017/5
N2 - Over the last decade, microRNAs have emerged as critical regulators in the expression and function of animal genomes. This review article discusses the relationship between microRNA-mediated regulation and the biology of the fruit fly Drosophila melanogaster. We focus on the roles that microRNAs play in tissue growth, germ cell development, hormone action, and the development and activity of the central nervous system. We also discuss the ways in which microRNAs affect robustness. Many gene regulatory networks are robust; they are relatively insensitive to the precise values of reaction constants and concentrations of molecules acting within the networks. MicroRNAs involved in robustness appear to be nonessential under uniform conditions used in conventional laboratory experiments. However, the robust functions of microRNAs can be revealed when environmental or genetic variation otherwise has an impact on developmental outcomes.
AB - Over the last decade, microRNAs have emerged as critical regulators in the expression and function of animal genomes. This review article discusses the relationship between microRNA-mediated regulation and the biology of the fruit fly Drosophila melanogaster. We focus on the roles that microRNAs play in tissue growth, germ cell development, hormone action, and the development and activity of the central nervous system. We also discuss the ways in which microRNAs affect robustness. Many gene regulatory networks are robust; they are relatively insensitive to the precise values of reaction constants and concentrations of molecules acting within the networks. MicroRNAs involved in robustness appear to be nonessential under uniform conditions used in conventional laboratory experiments. However, the robust functions of microRNAs can be revealed when environmental or genetic variation otherwise has an impact on developmental outcomes.
KW - Drosophila
KW - MiRNAs
KW - MicroRNAs
UR - http://www.scopus.com/inward/record.url?scp=84962272062&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84962272062&partnerID=8YFLogxK
U2 - 10.1016/j.semcdb.2016.03.015
DO - 10.1016/j.semcdb.2016.03.015
M3 - Review article
C2 - 27000418
AN - SCOPUS:84962272062
VL - 65
SP - 29
EP - 37
JO - Seminars in Cell and Developmental Biology
JF - Seminars in Cell and Developmental Biology
SN - 1084-9521
ER -