MicroRNAs-449a and -449b exhibit tumor suppressive effects in retinoblastoma

Alissa Martin; Aunica Jones; Paul J. Bryar; Marilyn Mets; Joanna Weinstein; Gang Zhang; Nikia A. Laurie

doi:10.1016/j.bbrc.2013.09.117

MicroRNAs-449a and -449b exhibit tumor suppressive effects in retinoblastoma

Alissa Martin, Aunica Jones, Paul J. Bryar, Marilyn Mets, Joanna Weinstein, Gang Zhang, Nikia A. Laurie^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Retinoblastoma is the most common pediatric cancer of the eye. Currently, the chemotherapeutic treatments for retinoblastoma are broad-based drugs such as vincristine, carboplatin, or etoposide. However, therapies targeted directly to aberrant signaling pathways may provide more effective therapy for this disease. The purpose of our study is to illustrate the relationship between the expressions of miRs-449a and -449b to retinoblastoma proliferation and apoptosis. We are the first to confirm an inhibitory effect of miR-449a and -449b in retinoblastoma by demonstrating significantly impaired proliferation and increased apoptosis of tumor cells when these miRNAs are overexpressed. This study suggests that these miRNAs could serve as viable therapeutic targets for retinoblastoma treatment.

Original language	English (US)
Pages (from-to)	599-603
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	440
Issue number	4
DOIs	https://doi.org/10.1016/j.bbrc.2013.09.117
State	Published - Nov 1 2013

Funding

The authors would like to thank Aaliyah Hamidullah and Jatuphon Chaiseesiri for technical assistance, and Elaine Hanrahan for administrative assistance. This work was supported by the Illinois Department of Public Health – Excellence in Academic Medicine Award (to N.A.L.) and Research to Prevent Blindness Inc. NY, NY (to P.B.).

Keywords

Apoptosis
MicroRNA
Proliferation
Retina
Retinoblastoma

ASJC Scopus subject areas

Molecular Biology
Biophysics
Biochemistry
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bbrc.2013.09.117

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title = "MicroRNAs-449a and -449b exhibit tumor suppressive effects in retinoblastoma",

abstract = "Retinoblastoma is the most common pediatric cancer of the eye. Currently, the chemotherapeutic treatments for retinoblastoma are broad-based drugs such as vincristine, carboplatin, or etoposide. However, therapies targeted directly to aberrant signaling pathways may provide more effective therapy for this disease. The purpose of our study is to illustrate the relationship between the expressions of miRs-449a and -449b to retinoblastoma proliferation and apoptosis. We are the first to confirm an inhibitory effect of miR-449a and -449b in retinoblastoma by demonstrating significantly impaired proliferation and increased apoptosis of tumor cells when these miRNAs are overexpressed. This study suggests that these miRNAs could serve as viable therapeutic targets for retinoblastoma treatment.",

keywords = "Apoptosis, MicroRNA, Proliferation, Retina, Retinoblastoma",

author = "Alissa Martin and Aunica Jones and Bryar, {Paul J.} and Marilyn Mets and Joanna Weinstein and Gang Zhang and Laurie, {Nikia A.}",

note = "Funding Information: The authors would like to thank Aaliyah Hamidullah and Jatuphon Chaiseesiri for technical assistance, and Elaine Hanrahan for administrative assistance. This work was supported by the Illinois Department of Public Health – Excellence in Academic Medicine Award (to N.A.L.) and Research to Prevent Blindness Inc. NY, NY (to P.B.).",

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AU - Martin, Alissa

AU - Jones, Aunica

AU - Bryar, Paul J.

AU - Mets, Marilyn

AU - Weinstein, Joanna

AU - Zhang, Gang

AU - Laurie, Nikia A.

N1 - Funding Information: The authors would like to thank Aaliyah Hamidullah and Jatuphon Chaiseesiri for technical assistance, and Elaine Hanrahan for administrative assistance. This work was supported by the Illinois Department of Public Health – Excellence in Academic Medicine Award (to N.A.L.) and Research to Prevent Blindness Inc. NY, NY (to P.B.).

PY - 2013/11/1

Y1 - 2013/11/1

N2 - Retinoblastoma is the most common pediatric cancer of the eye. Currently, the chemotherapeutic treatments for retinoblastoma are broad-based drugs such as vincristine, carboplatin, or etoposide. However, therapies targeted directly to aberrant signaling pathways may provide more effective therapy for this disease. The purpose of our study is to illustrate the relationship between the expressions of miRs-449a and -449b to retinoblastoma proliferation and apoptosis. We are the first to confirm an inhibitory effect of miR-449a and -449b in retinoblastoma by demonstrating significantly impaired proliferation and increased apoptosis of tumor cells when these miRNAs are overexpressed. This study suggests that these miRNAs could serve as viable therapeutic targets for retinoblastoma treatment.

AB - Retinoblastoma is the most common pediatric cancer of the eye. Currently, the chemotherapeutic treatments for retinoblastoma are broad-based drugs such as vincristine, carboplatin, or etoposide. However, therapies targeted directly to aberrant signaling pathways may provide more effective therapy for this disease. The purpose of our study is to illustrate the relationship between the expressions of miRs-449a and -449b to retinoblastoma proliferation and apoptosis. We are the first to confirm an inhibitory effect of miR-449a and -449b in retinoblastoma by demonstrating significantly impaired proliferation and increased apoptosis of tumor cells when these miRNAs are overexpressed. This study suggests that these miRNAs could serve as viable therapeutic targets for retinoblastoma treatment.

KW - Apoptosis

KW - MicroRNA

KW - Proliferation

KW - Retina

KW - Retinoblastoma

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ER -

MicroRNAs-449a and -449b exhibit tumor suppressive effects in retinoblastoma

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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