MicroRNAs-449a and -449b exhibit tumor suppressive effects in retinoblastoma

Alissa Martin, Aunica Jones, Paul Bryar, Marilyn B Mets, Joanna Lynn Weinstein, Gang Zhang, Nikia A Laurie*

*Corresponding author for this work

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Retinoblastoma is the most common pediatric cancer of the eye. Currently, the chemotherapeutic treatments for retinoblastoma are broad-based drugs such as vincristine, carboplatin, or etoposide. However, therapies targeted directly to aberrant signaling pathways may provide more effective therapy for this disease. The purpose of our study is to illustrate the relationship between the expressions of miRs-449a and -449b to retinoblastoma proliferation and apoptosis. We are the first to confirm an inhibitory effect of miR-449a and -449b in retinoblastoma by demonstrating significantly impaired proliferation and increased apoptosis of tumor cells when these miRNAs are overexpressed. This study suggests that these miRNAs could serve as viable therapeutic targets for retinoblastoma treatment.

Original languageEnglish (US)
Pages (from-to)599-603
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume440
Issue number4
DOIs
StatePublished - Nov 1 2013

Fingerprint

Retinoblastoma
MicroRNAs
Tumors
Apoptosis
Pediatrics
Carboplatin
Vincristine
Etoposide
Neoplasms
Cells
Eye Neoplasms
Pharmaceutical Preparations
Therapeutics

Keywords

  • Apoptosis
  • MicroRNA
  • Proliferation
  • Retina
  • Retinoblastoma

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

Cite this

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abstract = "Retinoblastoma is the most common pediatric cancer of the eye. Currently, the chemotherapeutic treatments for retinoblastoma are broad-based drugs such as vincristine, carboplatin, or etoposide. However, therapies targeted directly to aberrant signaling pathways may provide more effective therapy for this disease. The purpose of our study is to illustrate the relationship between the expressions of miRs-449a and -449b to retinoblastoma proliferation and apoptosis. We are the first to confirm an inhibitory effect of miR-449a and -449b in retinoblastoma by demonstrating significantly impaired proliferation and increased apoptosis of tumor cells when these miRNAs are overexpressed. This study suggests that these miRNAs could serve as viable therapeutic targets for retinoblastoma treatment.",
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MicroRNAs-449a and -449b exhibit tumor suppressive effects in retinoblastoma. / Martin, Alissa; Jones, Aunica; Bryar, Paul; Mets, Marilyn B; Weinstein, Joanna Lynn; Zhang, Gang; Laurie, Nikia A.

In: Biochemical and Biophysical Research Communications, Vol. 440, No. 4, 01.11.2013, p. 599-603.

Research output: Contribution to journalArticle

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AU - Martin, Alissa

AU - Jones, Aunica

AU - Bryar, Paul

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AU - Weinstein, Joanna Lynn

AU - Zhang, Gang

AU - Laurie, Nikia A

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AB - Retinoblastoma is the most common pediatric cancer of the eye. Currently, the chemotherapeutic treatments for retinoblastoma are broad-based drugs such as vincristine, carboplatin, or etoposide. However, therapies targeted directly to aberrant signaling pathways may provide more effective therapy for this disease. The purpose of our study is to illustrate the relationship between the expressions of miRs-449a and -449b to retinoblastoma proliferation and apoptosis. We are the first to confirm an inhibitory effect of miR-449a and -449b in retinoblastoma by demonstrating significantly impaired proliferation and increased apoptosis of tumor cells when these miRNAs are overexpressed. This study suggests that these miRNAs could serve as viable therapeutic targets for retinoblastoma treatment.

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