microRNAs and death receptors

Sun Mi Park, Marcus E. Peter*

*Corresponding author for this work

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Death receptors induce apoptosis through either the Type I or II pathway. In Type I cells, the initiator caspase-8 directly activates effector caspases such as caspase-3, whereas in Type II cells, the death signal is amplified through mitochondria thereby activating effector caspases causing cell death. Recently, there have been advances in elucidating the early events in the CD95 signaling pathways and how post-translational modifications regulate CD95 signaling. This review will focus on recent insights into the mechanisms of the two different types of CD95 signaling pathways, and will introduce miRNAs as regulators of death receptor signaling.

Original languageEnglish (US)
Pages (from-to)303-311
Number of pages9
JournalCytokine and Growth Factor Reviews
Volume19
Issue number3-4
DOIs
StatePublished - Jun 1 2008

Keywords

  • Apoptosis
  • Fas
  • Let-7
  • Superclusters
  • TRAIL

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

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