MicroRNAs as novel immunotherapeutics

Amy B. Heimberger; Mark Gilbert; Ganesh Rao; Jun Wei

doi:10.4161/onci.25124

MicroRNAs as novel immunotherapeutics

Amy B. Heimberger^*, Mark Gilbert, Ganesh Rao, Jun Wei

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

A large unmet need exists for cost-effective, widely available antineoplastic immunotherapeutic agents with a robust translational potential. MicroRNAs (miRNAs) that regulate tumor-mediated immunosuppression or immune checkpoints can induce robust therapeutic immune responses, indicating that miRNAs may ultimately become part of the portfolio of anticancer immunotherapeutics.

Original language	English (US)
Article number	e25124
Journal	OncoImmunology
Volume	2
Issue number	8
DOIs	https://doi.org/10.4161/onci.25124
State	Published - 2013
Externally published	Yes

Keywords

Cancer stem cells
Glioblastoma multiforme
Immunosuppression
MicroRNAs
Regulatory T cells
Signal transducer and activator of transcription 3

ASJC Scopus subject areas

Oncology
Immunology and Allergy
Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.4161/onci.25124

Cite this

@article{5e86f1f175674d8fa3630f9a03fb4e95,

title = "MicroRNAs as novel immunotherapeutics",

abstract = "A large unmet need exists for cost-effective, widely available antineoplastic immunotherapeutic agents with a robust translational potential. MicroRNAs (miRNAs) that regulate tumor-mediated immunosuppression or immune checkpoints can induce robust therapeutic immune responses, indicating that miRNAs may ultimately become part of the portfolio of anticancer immunotherapeutics.",

keywords = "Cancer stem cells, Glioblastoma multiforme, Immunosuppression, MicroRNAs, Regulatory T cells, Signal transducer and activator of transcription 3",

author = "Heimberger, {Amy B.} and Mark Gilbert and Ganesh Rao and Jun Wei",

year = "2013",

doi = "10.4161/onci.25124",

language = "English (US)",

volume = "2",

journal = "OncoImmunology",

issn = "2162-4011",

publisher = "Landes Bioscience",

number = "8",

}

TY - JOUR

T1 - MicroRNAs as novel immunotherapeutics

AU - Heimberger, Amy B.

AU - Gilbert, Mark

AU - Rao, Ganesh

AU - Wei, Jun

PY - 2013

Y1 - 2013

N2 - A large unmet need exists for cost-effective, widely available antineoplastic immunotherapeutic agents with a robust translational potential. MicroRNAs (miRNAs) that regulate tumor-mediated immunosuppression or immune checkpoints can induce robust therapeutic immune responses, indicating that miRNAs may ultimately become part of the portfolio of anticancer immunotherapeutics.

AB - A large unmet need exists for cost-effective, widely available antineoplastic immunotherapeutic agents with a robust translational potential. MicroRNAs (miRNAs) that regulate tumor-mediated immunosuppression or immune checkpoints can induce robust therapeutic immune responses, indicating that miRNAs may ultimately become part of the portfolio of anticancer immunotherapeutics.

KW - Cancer stem cells

KW - Glioblastoma multiforme

KW - Immunosuppression

KW - MicroRNAs

KW - Regulatory T cells

KW - Signal transducer and activator of transcription 3

UR - http://www.scopus.com/inward/record.url?scp=84885744161&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84885744161&partnerID=8YFLogxK

U2 - 10.4161/onci.25124

DO - 10.4161/onci.25124

M3 - Article

C2 - 24083077

AN - SCOPUS:84885744161

SN - 2162-4011

VL - 2

JO - OncoImmunology

JF - OncoImmunology

IS - 8

M1 - e25124

ER -

MicroRNAs as novel immunotherapeutics

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this