MicroRNAs as novel immunotherapeutics

Amy B. Heimberger*, Mark Gilbert, Ganesh Rao, Jun Wei

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

A large unmet need exists for cost-effective, widely available antineoplastic immunotherapeutic agents with a robust translational potential. MicroRNAs (miRNAs) that regulate tumor-mediated immunosuppression or immune checkpoints can induce robust therapeutic immune responses, indicating that miRNAs may ultimately become part of the portfolio of anticancer immunotherapeutics.

Original languageEnglish (US)
Article numbere25124
JournalOncoImmunology
Volume2
Issue number8
DOIs
StatePublished - 2013
Externally publishedYes

Keywords

  • Cancer stem cells
  • Glioblastoma multiforme
  • Immunosuppression
  • MicroRNAs
  • Regulatory T cells
  • Signal transducer and activator of transcription 3

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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