MicroRNAs in breast cancer initiation and progression

Huiping Liu*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations

Abstract

The emerging role of microRNAs (miRNAs) in the epigenetic regulation of many cellular processes has become recognized in both basic research and translational medicine as an important way that gene expression can be fine-tuned. Breast cancer is the most frequent cancer in women, with about one million new cases diagnosed each year worldwide. Starting with the early work of miRNA profiling, more effort has now been put on functions of miRNAs in normal mammary stem cells, breast cancer initiating cells and metastatic cells, and therapy-resistant cancer cells. Future translational studies may focus on identifying miRNA signatures as cancer biomarkers and developing miRNA-based targeted therapeutics.

Original languageEnglish (US)
Pages (from-to)3587-3599
Number of pages13
JournalCellular and Molecular Life Sciences
Volume69
Issue number21
DOIs
StatePublished - Nov 2012

Keywords

  • Breast cancer stem cells
  • Metastasis
  • MiRNA biomarkers
  • MiRNA therapeutics
  • MicroRNAs
  • Therapy resistance

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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