MicroRNAs in Neural Crest Development

C. Shekhar Mayanil*, M. Rizwan Siddiqui, Shunsuke Ichi, Barbara Mania-Farnell, Tadanori Tomita, David McLone

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

The neural crest (NC) is a population of cells between the dorsal ectoderm and the neural tube in vertebrate embryos. Regulatory mechanisms ranging from epigenetics to microRNAs (miRNAs) to post-translational protein modifications, work coordinately to fine-tune NC activity. miRNAs affect genes transcriptionally by directly interacting with either their 3'UTR or their 5'UTR. Affected genes include those of chromatin-modifying enzymes such as EZH2 and KDM6B. A lack of optimal levels of chromatin-modifying enzymes may in turn affect miRNA biogenesis as well as the transcriptional regulation of other genes. Overall, noncoding RNA genes and protein-coding genes interact in a network that, when connected to chromatin regulation, affects the expression of both noncoding and coding genes in neural crest development. This chapter highlights that role.

Original languageEnglish (US)
Title of host publicationMicroRNA in Regenerative Medicine
PublisherElsevier Inc
Pages515-538
Number of pages24
ISBN (Electronic)9780124058583
ISBN (Print)9780124055445
DOIs
StatePublished - Jan 1 2015

Keywords

  • Epigenetics
  • MiRNA
  • MicroRNA
  • Neural crest
  • Neural crest stem cells
  • Neural tube

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

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