MicroRNAs in Neural Crest Development

C. Shekhar Mayanil; M. Rizwan Siddiqui; Shunsuke Ichi; Barbara Mania-Farnell; Tadanori Tomita; David McLone

doi:10.1016/B978-0-12-405544-5.00020-4

MicroRNAs in Neural Crest Development

C. Shekhar Mayanil^*, M. Rizwan Siddiqui, Shunsuke Ichi, Barbara Mania-Farnell, Tadanori Tomita, David McLone

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

The neural crest (NC) is a population of cells between the dorsal ectoderm and the neural tube in vertebrate embryos. Regulatory mechanisms ranging from epigenetics to microRNAs (miRNAs) to post-translational protein modifications, work coordinately to fine-tune NC activity. miRNAs affect genes transcriptionally by directly interacting with either their 3'UTR or their 5'UTR. Affected genes include those of chromatin-modifying enzymes such as EZH2 and KDM6B. A lack of optimal levels of chromatin-modifying enzymes may in turn affect miRNA biogenesis as well as the transcriptional regulation of other genes. Overall, noncoding RNA genes and protein-coding genes interact in a network that, when connected to chromatin regulation, affects the expression of both noncoding and coding genes in neural crest development. This chapter highlights that role.

Original language	English (US)
Title of host publication	MicroRNA in Regenerative Medicine
Publisher	Elsevier Inc
Pages	515-538
Number of pages	24
ISBN (Electronic)	9780124058583
ISBN (Print)	9780124055445
DOIs	https://doi.org/10.1016/B978-0-12-405544-5.00020-4
State	Published - Jan 1 2015

Keywords

Epigenetics
MiRNA
MicroRNA
Neural crest
Neural crest stem cells
Neural tube

ASJC Scopus subject areas

General Immunology and Microbiology

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10.1016/B978-0-12-405544-5.00020-4

Cite this

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title = "MicroRNAs in Neural Crest Development",

abstract = "The neural crest (NC) is a population of cells between the dorsal ectoderm and the neural tube in vertebrate embryos. Regulatory mechanisms ranging from epigenetics to microRNAs (miRNAs) to post-translational protein modifications, work coordinately to fine-tune NC activity. miRNAs affect genes transcriptionally by directly interacting with either their 3'UTR or their 5'UTR. Affected genes include those of chromatin-modifying enzymes such as EZH2 and KDM6B. A lack of optimal levels of chromatin-modifying enzymes may in turn affect miRNA biogenesis as well as the transcriptional regulation of other genes. Overall, noncoding RNA genes and protein-coding genes interact in a network that, when connected to chromatin regulation, affects the expression of both noncoding and coding genes in neural crest development. This chapter highlights that role.",

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AU - Mayanil, C. Shekhar

AU - Siddiqui, M. Rizwan

AU - Ichi, Shunsuke

AU - Mania-Farnell, Barbara

AU - Tomita, Tadanori

AU - McLone, David

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N2 - The neural crest (NC) is a population of cells between the dorsal ectoderm and the neural tube in vertebrate embryos. Regulatory mechanisms ranging from epigenetics to microRNAs (miRNAs) to post-translational protein modifications, work coordinately to fine-tune NC activity. miRNAs affect genes transcriptionally by directly interacting with either their 3'UTR or their 5'UTR. Affected genes include those of chromatin-modifying enzymes such as EZH2 and KDM6B. A lack of optimal levels of chromatin-modifying enzymes may in turn affect miRNA biogenesis as well as the transcriptional regulation of other genes. Overall, noncoding RNA genes and protein-coding genes interact in a network that, when connected to chromatin regulation, affects the expression of both noncoding and coding genes in neural crest development. This chapter highlights that role.

AB - The neural crest (NC) is a population of cells between the dorsal ectoderm and the neural tube in vertebrate embryos. Regulatory mechanisms ranging from epigenetics to microRNAs (miRNAs) to post-translational protein modifications, work coordinately to fine-tune NC activity. miRNAs affect genes transcriptionally by directly interacting with either their 3'UTR or their 5'UTR. Affected genes include those of chromatin-modifying enzymes such as EZH2 and KDM6B. A lack of optimal levels of chromatin-modifying enzymes may in turn affect miRNA biogenesis as well as the transcriptional regulation of other genes. Overall, noncoding RNA genes and protein-coding genes interact in a network that, when connected to chromatin regulation, affects the expression of both noncoding and coding genes in neural crest development. This chapter highlights that role.

KW - Epigenetics

KW - MiRNA

KW - MicroRNA

KW - Neural crest

KW - Neural crest stem cells

KW - Neural tube

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BT - MicroRNA in Regenerative Medicine

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MicroRNAs in Neural Crest Development

Abstract

Keywords

ASJC Scopus subject areas

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