MicroRNAs regulate both epithelial-to-mesenchymal transition and cancer stem cells

P. Ceppi, M. E. Peter*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

80 Scopus citations

Abstract

Concepts and experimental models derived from basic research have been successfully applied to the field of molecular oncology, tremendously increasing our knowledge of the nature and the progression of tumors. The process of epithelial-to-mesenchymal transition, the cancer stem cell hypothesis, and their functional association and interdependence represent some of the most significant examples. The molecular determinants underlying the plasticity of cancers are currently the object of extensive research efforts, and a substantial body of evidence suggests that these models can be connected by the regulatory role of microRNAs, small noncoding RNA molecules with a fundamental role in many cellular functions. This review will highlight and discuss this link and its possible implications for the fight against cancer.

Original languageEnglish (US)
Pages (from-to)269-278
Number of pages10
JournalOncogene
Volume33
Issue number3
DOIs
StatePublished - Jan 16 2014

Keywords

  • MiRNAs
  • cancer stem cells
  • epithelial-to-mesenchymal transition

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Fingerprint Dive into the research topics of 'MicroRNAs regulate both epithelial-to-mesenchymal transition and cancer stem cells'. Together they form a unique fingerprint.

Cite this