TY - JOUR
T1 - Microtubule-based transport and the distribution, tethering, and organization of organelles
AU - Barlan, Kari
AU - Gelfand, Vladimir I.
N1 - Funding Information:
We are extremely grateful to Nico Camargo for creating the illustrations used in Figure 1. We also extend sincere thanks to Gulcin Pekkurnaz and Tom Schwarz for providing illustrations and micrographs used in Figure 2, aswell as Xufeng Wu and John Hammer for micrographs used in Figure 3. Research in the Gelfand laboratory is supported by the National Institute of General Medical Science of the National Institutes of Health under award numbers R01GM052111 and P01GM096971. K.B. is a Howard Hughes Medical Institute Fellow of the Life Sciences Research Foundation.
Publisher Copyright:
© 2017 Cold Spring Harbor Laboratory Press; all rights reserved.
PY - 2017/5
Y1 - 2017/5
N2 - Microtubules provide long tracks along which a broad range of organelles and vesicles are transported by kinesin and dynein motors. Motor protein complexes also tether cargoes to cytoskeletal filaments, helping facilitate their interaction and communication. The generation of biochemically distinct microtubule subpopulations allows subsets of motors to recognize a given microtubule identity, allowing further organization within the cytoplasm. Both transport and tethering are spatiotemporally regulated through multiple modes, including acute modification of both motor–cargo and motor–track associations by various physiological signals. Strict regulation of intracellular transport is particularly important in specialized cell types such as neurons. Here, we review general mechanisms by which cargo transport is controlled and also highlight examples of transport regulated by multiple mechanisms.
AB - Microtubules provide long tracks along which a broad range of organelles and vesicles are transported by kinesin and dynein motors. Motor protein complexes also tether cargoes to cytoskeletal filaments, helping facilitate their interaction and communication. The generation of biochemically distinct microtubule subpopulations allows subsets of motors to recognize a given microtubule identity, allowing further organization within the cytoplasm. Both transport and tethering are spatiotemporally regulated through multiple modes, including acute modification of both motor–cargo and motor–track associations by various physiological signals. Strict regulation of intracellular transport is particularly important in specialized cell types such as neurons. Here, we review general mechanisms by which cargo transport is controlled and also highlight examples of transport regulated by multiple mechanisms.
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U2 - 10.1101/cshperspect.a025817
DO - 10.1101/cshperspect.a025817
M3 - Article
C2 - 28461574
AN - SCOPUS:85018760214
VL - 9
JO - Cold Spring Harbor perspectives in biology
JF - Cold Spring Harbor perspectives in biology
SN - 1943-0264
IS - 5
M1 - a025817
ER -