Microtubules and viral infection

Eveline Santos da Silva, Mojgan H. Naghavi*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter


Microtubules (MTs) form rapidly adaptable, complex intracellular networks of filaments that not only provide structural support, but also form the tracks along which motors traffic macromolecular cargos to specific sub-cellular sites. These dynamic arrays play a central role in regulating various cellular processes including cell shape and motility as well as cell division and polarization. Given their complex organization and functional importance, MT arrays are carefully controlled by many highly specialized proteins that regulate the nucleation of MT filaments at distinct sites, their dynamic growth and stability, and their engagement with other subcellular structures and cargoes destined for transport. This review focuses on recent advances in our understanding of how MTs and their regulatory proteins function, including their active targeting and exploitation, during infection by viruses that utilize a wide variety of replication strategies that occur within different cellular sub-compartments or regions of the cell.

Original languageEnglish (US)
Title of host publicationAdvances in Virus Research
EditorsMargaret Kielian, Marilyn J. Roossinck
PublisherAcademic Press Inc
Number of pages48
ISBN (Print)9780443193569
StatePublished - Jan 2023

Publication series

NameAdvances in Virus Research
ISSN (Print)0065-3527
ISSN (Electronic)1557-8399


  • Cytoskeleton
  • Microtubules
  • Motors
  • Trafficking
  • Virus

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases


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