Midazolam kinetics in women of two age groups

Michael J. Avram*, Robert J. Fragen, Nancy J. Caldwell

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Midazolam kinetics were determined in 11 younger (22 to 30 yr) and 11 older (50 to 60 yr) women to determine age-related differences in the kinetics of this water-soluble benzodiazepine. Midazolam, 0.2 mg/kg, was injected intravenously over 30 sec for induction of anesthesia that was maintained with 67% nitrous oxide in oxygen and intravenous fentanyl doses. There were no differences between the groups with respect to awakening times or plasma concentrations. Midazolam kinetics were described by a three-compartment open mamillary model. The only differences were small increases in the slow and total volumes of distribution in the older women. The kinetics we determined, including the steady-state volume of distribution of 1.23 l/kg and the elimination clearance of 419 ml/min, are in excellent agreement with those reported by others. Our data suggest that midazolam has advantages over other benzodiazepines, not only because of its water solubility and shorter elimination t 1 2, but also because of little change in its kinetics with age.

Original languageEnglish (US)
Pages (from-to)505-508
Number of pages4
JournalClinical pharmacology and therapeutics
Volume34
Issue number4
DOIs
StatePublished - Oct 1983

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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