Midline crossing and Slit responsiveness of commissural axons require USP33

Junichi Yuasa-Kawada, Mariko Kinoshita-Kawada, Guan Wu, Yi Rao*, Jane Y. Wu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Commissural axons cross the ventral midline of the neural tube in a Slit-dependent manner. The underlying molecular mechanisms remain unclear. We found that the deubiquitinating enzyme USP33 interacts with the Robo1 receptor. USP33 was essential for midline crossing by commissural axons and for their response to Slit. Our results reveal a previously unknown role for USP33 in vertebrate commissural axon guidance and in Slit signaling.

Original languageEnglish (US)
Pages (from-to)1087-1089
Number of pages3
JournalNature neuroscience
Volume12
Issue number9
DOIs
StatePublished - Sep 2009

ASJC Scopus subject areas

  • Neuroscience(all)

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