Midtrimester amniocentesis: Influence of operator caseload on sampling efficiency

R. K. Silver*, T. L. Russell, M. P. Kambich, E. A. Leeth, S. N. McGregor, J. S. Sholl

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


OBJECTIVE: To evaluate the impact of operator caseload on the sampling efficiency for early and standard, midtrimester amniocentesis. STUDY DESIGN: Prospective ascertainment of genetic amniocenteses performed during 36 months, grouped into early (13-14 weeks' gestation) and standard procedures (15-20 weeks' gestation). Details of each amniocentesis were recorded immediately after sampling, and pregnancy outcomes were retrieved via questionnaires completed by the delivering physician. Sampling efficiency was evaluated separately in the early and standard cohorts in relation to operator caseload. RESULTS: In total, 193 and 707 patients underwent early and standard amniocentesis, respectively. Forty of 46 physician-operators performed < 50 total procedures during the study interval (group A). When compared to operators performing >50 cases (group B, n = 6), a higher rate of single-pass success was noted among group B physicians for both early and standard procedures (A vs. B, early: 40/45 vs. 145/148, P = .018; standard: 243/295 vs. 384/412, P < .0001). Logistic regression confirmed an independent effect of physician caseload on sampling efficiency and a significant interaction between physician caseload and simultaneous ultrasound guidance in predicting single-attempt success. CONCLUSION: Operator: caseload-directly influenced sampling efficiency for both early anti, standard, midtrimester amniocentesis.

Original languageEnglish (US)
Pages (from-to)191-195
Number of pages5
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Issue number3 SUPPL.
StatePublished - Apr 27 1998


  • Amniocentesis
  • Caseload
  • Prenatal diagnosis

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine


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