Mild amidation of aldehydes with amines mediated by lanthanide catalysts

Sung Yong Seo, Tobin J. Marks*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

192 Scopus citations


(Chemical Equation Presented) Catalytic amidation of aldehydes with amines is efficiently mediated by homoleptic lanthanide amido complexes, Ln[N(SiMe 3)2]3 (Ln = La, Sm, and Y). Amidation reactivity follows the trend: La > Sm ≈ Y. These reactions proceed in high yield without added oxidants, bases, and/or heat or light, which are usually required in other catalytic amidation processes. The reaction is demonstrated with a variety of amines, with yields as high as 98% based on amine.

Original languageEnglish (US)
Pages (from-to)317-319
Number of pages3
JournalOrganic Letters
Issue number2
StatePublished - Jan 17 2008

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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