Mild cognitive impairment: an update in Parkinson's disease and lessons learned from Alzheimer's disease

Jennifer G Goldman, Neelum T. Aggarwal, Cynthia D. Schroeder

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations

Abstract

Cognitive dysfunction is an important focus of research in Parkinson's disease (PD) and Alzheimer's disease (AD). While the concept of amnestic mild cognitive impairment (MCI) as a prodrome to AD has been recognized for many years, the construct of MCI in PD is a relative newcomer with recent development of diagnostic criteria, biomarker research programs and treatment trials. Controversies and challenges, however, regarding PD-MCI's definition, application, heterogeneity and different trajectories have arisen. This review will highlight current research advances and challenges in PD-MCI. Furthermore, lessons from the AD field, which has witnessed an evolution in MCI/AD definitions, relevant advances in biomarker research and development of disease-modifying and targeted therapeutic trials will be discussed.

Original languageEnglish (US)
Pages (from-to)425-443
Number of pages19
JournalNeurodegenerative disease management
Volume5
Issue number5
DOIs
StatePublished - Oct 1 2015

Keywords

  • Alzheimer's disease
  • Parkinson's disease
  • amnestic
  • biomarker
  • cognitive
  • dementia
  • diagnostic criteria
  • executive function
  • mild cognitive impairment
  • nonamnestic

ASJC Scopus subject areas

  • Medicine(all)

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