Mild cognitive impairment in Parkinson's disease

Jennifer G Goldman*, I. Litvan

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

108 Scopus citations

Abstract

Parkinson's disease (PD) traditionally has been defined by its characteristic motor hallmarks, but non-motor features such as cognitive impairment and dementia are increasingly recognized as part of PD. Mild cognitive impairment (MCI) is common in non-demented PD patients, occurring in about 20-50%. Frequency estimates and clinical features of mild cognitive impairment in PD (PD-MCI), however, vary across studies due to methodological differences and lack of uniform diagnostic criteria for PD-MCI. Overall, PD-MCI patients exhibit nonamnestic deficits in cognitive domains such as executive function, attention, and visuospatial function; however, the cognitive phenotype of PD-MCI is heterogeneous with some patients demonstrating greater amnestic deficits. PD-MCI patients, particularly those with posterior cortical profiles, may be at high risk for developing dementia. Various biomarkers studied in PD-MCI including cerebrospinal fluid, genetic analyses, and neuroimaging suggest that there may be distinct PD-MCI profiles. Future studies using uniform PD-MCI diagnostic criteria and incorporating biomarkers and longitudinal follow-up of PD-MCI cohorts are needed to understand PD-MCI as a transitional state between normal cognition and dementia.

Original languageEnglish (US)
Pages (from-to)441-459
Number of pages19
JournalMinerva Medica
Volume102
Issue number6
StatePublished - Dec 2011

Keywords

  • Alzheimer disease
  • Dementia
  • Parkinson disease
  • Psychomotor disorders

ASJC Scopus subject areas

  • Medicine(all)

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