Mild traumatic brain injury exacerbates Parkinson's disease induced hemeoxygenase-2 expression and brain pathology: Neuroprotective effects of co-administration of TiO2 nanowired mesenchymal stem cells and cerebrolysin

Aruna Sharma; Dafin F. Muresanu; Rudy J. Castellani; Ala Nozari; José Vicente Lafuente; Seaab Sahib; Z. Ryan Tian; Anca D. Buzoianu; Ranjana Patnaik; Lars Wiklund; Hari Shanker Sharma

doi:10.1016/bs.pbr.2020.09.010

Mild traumatic brain injury exacerbates Parkinson's disease induced hemeoxygenase-2 expression and brain pathology: Neuroprotective effects of co-administration of TiO₂ nanowired mesenchymal stem cells and cerebrolysin

Aruna Sharma^*, Dafin F. Muresanu, Rudy J. Castellani, Ala Nozari, José Vicente Lafuente, Seaab Sahib, Z. Ryan Tian, Anca D. Buzoianu, Ranjana Patnaik, Lars Wiklund, Hari Shanker Sharma

^*Corresponding author for this work

Pathology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

24 Scopus citations

Abstract

Mild traumatic brain injury (mTBI) is one of the leading predisposing factors in the development of Parkinson's disease (PD). Mild or moderate TBI induces rapid production of tau protein and alpha synuclein (ASNC) in the cerebrospinal fluid (CSF) and in several brain areas. Enhanced tau-phosphorylation and ASNC alters the molecular machinery of the brain leading to PD pathology. Recent evidences show upregulation of constitutive isoform of hemeoxygenase (HO-2) in PD patients that correlates well with the brain pathology. mTBI alone induces profound upregulation of HO-2 immunoreactivity. Thus, it would be interesting to explore whether mTBI exacerbates PD pathology in relation to tau, ASNC and HO-2 expression. In addition, whether neurotrophic factors and stem cells known to reduce brain pathology in TBI could induce neuroprotection in PD following mTBI. In this review role of mesenchymal stem cells (MSCs) and cerebrolysin (CBL), a well-balanced composition of several neurotrophic factors and active peptide fragments using nanowired delivery in PD following mTBI is discussed based on our own investigation. Our results show that mTBI induces concussion exacerbates PD pathology and nanowired delivery of MSCs and CBL induces superior neuroprotection. This could be due to reduction in tau, ASNC and HO-2 expression in PD following mTBI, not reported earlier. The functional significance of our findings in relation to clinical strategies is discussed.

Original language	English (US)
Title of host publication	Neuropharmacology of Neuroprotection
Editors	Hari Shanker Sharma, Aruna Sharma
Publisher	Elsevier B.V.
Pages	157-231
Number of pages	75
ISBN (Print)	9780128208137
DOIs	https://doi.org/10.1016/bs.pbr.2020.09.010
State	Published - Jan 2020

Publication series

Name	Progress in Brain Research
Volume	258
ISSN (Print)	0079-6123
ISSN (Electronic)	1875-7855

Funding

This investigation is supported by grants from the Air Force Office of Scientific Research (EOARD, London, UK), and Air Force Material Command, USAF, under grant number FA8655-05-1-3065; Grants from the Alzheimer's Association (IIRG-09-132087), the National Institutes of Health (R01 AG028679) and the Dr. Robert M. Kohrman Memorial Fund (R.J.C.); Swedish Medical Research Council (Nr. 2710-HSS), Göran Gustafsson Foundation, Stockholm, Sweden (H.S.S.), Astra Zeneca, Mölndal, Sweden (H.S.S./A.S.), Alexander von Humboldt Foundation, Bonn, Germany (H.S.S.), The University Grants Commission, New Delhi, India (H.S.S./A.S.), Ministry of Science & Technology, Govt. of India (H.S.S./A.S.), Indian Medical Research Council, New Delhi, India (H.S.S./A.S.) and India-EU Co-operation Program (R.P./A.S./H.S.S.) and IT-901/16 (J.V.L.), Government of Basque Country and PPG 17/51 (J.V.L.), J.V.L. thanks to the support of the University of the Basque Country (UPV/EHU) PPG 17/51 and 14/08, the Basque Government (IT-901/16 and CS-2203) Basque Country, Spain; and Foundation for Nanoneuroscience and Nanoneuroprotection (FSNN), Romania. Technical assistance of Kärstin Flink, Ingmarie Olsson, Uppsala University and Franzisca Drum, Katja Deparade, Free University Berlin, Germany are highly appreciated. Technical and human support provided by Dr. Ricardo Andrade from SGIker (UPV/EHU) is gratefully acknowledged. Dr. Seaab Sahib is supported by Research Fellowship at University of Arkansas Fayetteville AR, USA by Department of Community Health; Middle Technical University; Wassit; Iraq, and The Higher Committee for Education Development in Iraq; Baghdad; Iraq. We thank Suraj Sharma, Blekinge Inst. Technology, Karlskrona, Sweden and Dr. Saja Alshafeay, Fayetteville, AR, USA affiliated with University of Baghdad, Baghdad IQ, for computer and graphic support. The U.S. Government is authorized to reproduce and distribute reprints for Government purpose notwithstanding any copyright notation thereon. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of the Air Force Office of Scientific Research or the U.S. Government. The authors have no conflict of interests with any funding agency or entity reported here. This investigation is supported by grants from the Air Force Office of Scientific Research (EOARD, London, UK), and Air Force Material Command, USAF, under grant number FA8655-05-1-3065; Grants from the Alzheimer's Association (IIRG-09-132087), the National Institutes of Health (R01 AG028679) and the Dr. Robert M. Kohrman Memorial Fund (R.J.C.); Swedish Medical Research Council (Nr. 2710-HSS), Göran Gustafsson Foundation, Stockholm, Sweden (H.S.S.), Astra Zeneca, Mölndal, Sweden (H.S.S./A.S.), Alexander von Humboldt Foundation, Bonn, Germany (H.S.S.), The University Grants Commission, New Delhi, India (H.S.S./A.S.), Ministry of Science & Technology, Govt. of India (H.S.S./A.S.), Indian Medical Research Council, New Delhi, India (H.S.S./A.S.) and India-EU Co-operation Program (R.P./A.S./H.S.S.) and IT-901/16 (J.V.L.), Government of Basque Country and PPG 17/51 (J.V.L.), J.V.L. thanks to the support of the University of the Basque Country (UPV/EHU) PPG 17/51 and 14/08, the Basque Government (IT-901/16 and CS-2203) Basque Country, Spain; and Foundation for Nanoneuroscience and Nanoneuroprotection (FSNN), Romania. Technical assistance of Kärstin Flink, Ingmarie Olsson, Uppsala University and Franzisca Drum, Katja Deparade, Free University Berlin, Germany are highly appreciated. Technical and human support provided by Dr. Ricardo Andrade from SGIker (UPV/EHU) is gratefully acknowledged. Dr. Seaab Sahib is supported by Research Fellowship at University of Arkansas Fayetteville AR, USA by Department of Community Health; Middle Technical University; Wassit; Iraq, and The Higher Committee for Education Development in Iraq; Baghdad; Iraq. We thank Suraj Sharma, Blekinge Inst. Technology, Karlskrona, Sweden and Dr. Saja Alshafeay, Fayetteville, AR, USA affiliated with University of Baghdad, Baghdad IQ, for computer and graphic support. The U.S. Government is authorized to reproduce and distribute reprints for Government purpose notwithstanding any copyright notation thereon. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of the Air Force Office of Scientific Research or the U.S. Government.

Keywords

Alpha synuclein
Cerebrolysin
Concussive head injury
Hemeoxygenase-2
Mesenchymal stem cells
Nanowired drug delivery
Neuroprotection
Parkinson's disease
Tau
Traumatic brain injury

ASJC Scopus subject areas

General Neuroscience

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Sharma, A., Muresanu, D. F., Castellani, R. J., Nozari, A., Lafuente, J. V., Sahib, S., Tian, Z. R., Buzoianu, A. D., Patnaik, R., Wiklund, L., & Sharma, H. S. (2020). Mild traumatic brain injury exacerbates Parkinson's disease induced hemeoxygenase-2 expression and brain pathology: Neuroprotective effects of co-administration of TiO₂ nanowired mesenchymal stem cells and cerebrolysin. In H. S. Sharma, & A. Sharma (Eds.), Neuropharmacology of Neuroprotection (pp. 157-231). (Progress in Brain Research; Vol. 258). Elsevier B.V.. https://doi.org/10.1016/bs.pbr.2020.09.010

Sharma, Aruna ; Muresanu, Dafin F. ; Castellani, Rudy J. et al. / Mild traumatic brain injury exacerbates Parkinson's disease induced hemeoxygenase-2 expression and brain pathology : Neuroprotective effects of co-administration of TiO₂ nanowired mesenchymal stem cells and cerebrolysin. Neuropharmacology of Neuroprotection. editor / Hari Shanker Sharma ; Aruna Sharma. Elsevier B.V., 2020. pp. 157-231 (Progress in Brain Research).

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title = "Mild traumatic brain injury exacerbates Parkinson's disease induced hemeoxygenase-2 expression and brain pathology: Neuroprotective effects of co-administration of TiO2 nanowired mesenchymal stem cells and cerebrolysin",

abstract = "Mild traumatic brain injury (mTBI) is one of the leading predisposing factors in the development of Parkinson's disease (PD). Mild or moderate TBI induces rapid production of tau protein and alpha synuclein (ASNC) in the cerebrospinal fluid (CSF) and in several brain areas. Enhanced tau-phosphorylation and ASNC alters the molecular machinery of the brain leading to PD pathology. Recent evidences show upregulation of constitutive isoform of hemeoxygenase (HO-2) in PD patients that correlates well with the brain pathology. mTBI alone induces profound upregulation of HO-2 immunoreactivity. Thus, it would be interesting to explore whether mTBI exacerbates PD pathology in relation to tau, ASNC and HO-2 expression. In addition, whether neurotrophic factors and stem cells known to reduce brain pathology in TBI could induce neuroprotection in PD following mTBI. In this review role of mesenchymal stem cells (MSCs) and cerebrolysin (CBL), a well-balanced composition of several neurotrophic factors and active peptide fragments using nanowired delivery in PD following mTBI is discussed based on our own investigation. Our results show that mTBI induces concussion exacerbates PD pathology and nanowired delivery of MSCs and CBL induces superior neuroprotection. This could be due to reduction in tau, ASNC and HO-2 expression in PD following mTBI, not reported earlier. The functional significance of our findings in relation to clinical strategies is discussed.",

keywords = "Alpha synuclein, Cerebrolysin, Concussive head injury, Hemeoxygenase-2, Mesenchymal stem cells, Nanowired drug delivery, Neuroprotection, Parkinson's disease, Tau, Traumatic brain injury",

author = "Aruna Sharma and Muresanu, {Dafin F.} and Castellani, {Rudy J.} and Ala Nozari and Lafuente, {Jos{\'e} Vicente} and Seaab Sahib and Tian, {Z. Ryan} and Buzoianu, {Anca D.} and Ranjana Patnaik and Lars Wiklund and Sharma, {Hari Shanker}",

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year = "2020",

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doi = "10.1016/bs.pbr.2020.09.010",

language = "English (US)",

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publisher = "Elsevier B.V.",

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Sharma, A, Muresanu, DF, Castellani, RJ, Nozari, A, Lafuente, JV, Sahib, S, Tian, ZR, Buzoianu, AD, Patnaik, R, Wiklund, L & Sharma, HS 2020, Mild traumatic brain injury exacerbates Parkinson's disease induced hemeoxygenase-2 expression and brain pathology: Neuroprotective effects of co-administration of TiO₂ nanowired mesenchymal stem cells and cerebrolysin. in HS Sharma & A Sharma (eds), Neuropharmacology of Neuroprotection. Progress in Brain Research, vol. 258, Elsevier B.V., pp. 157-231. https://doi.org/10.1016/bs.pbr.2020.09.010

Mild traumatic brain injury exacerbates Parkinson's disease induced hemeoxygenase-2 expression and brain pathology: Neuroprotective effects of co-administration of TiO₂ nanowired mesenchymal stem cells and cerebrolysin. / Sharma, Aruna; Muresanu, Dafin F.; Castellani, Rudy J. et al.
Neuropharmacology of Neuroprotection. ed. / Hari Shanker Sharma; Aruna Sharma. Elsevier B.V., 2020. p. 157-231 (Progress in Brain Research; Vol. 258).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

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Sharma A, Muresanu DF, Castellani RJ, Nozari A, Lafuente JV, Sahib S et al. Mild traumatic brain injury exacerbates Parkinson's disease induced hemeoxygenase-2 expression and brain pathology: Neuroprotective effects of co-administration of TiO₂ nanowired mesenchymal stem cells and cerebrolysin. In Sharma HS, Sharma A, editors, Neuropharmacology of Neuroprotection. Elsevier B.V. 2020. p. 157-231. (Progress in Brain Research). doi: 10.1016/bs.pbr.2020.09.010