TY - JOUR
T1 - Mind the Gap
T2 - Sex Bias in Basic Skin Research
AU - Kong, Betty Y.
AU - Haugh, Isabel M.
AU - Schlosser, Bethanee J
AU - Getsios, Spiro
AU - Paller, Amy
PY - 2015/8/20
Y1 - 2015/8/20
N2 - Given the recent National Institutes of Health proposal for balanced use of male and female cells and animals in preclinical studies, we explored whether sex bias exists in skin research. We surveyed 802 dermatological research articles from 2012 to 2013. No information about the sex of studied cells or animals was provided in 60% of papers. Among keratinocytes of known sex, 70% were male. Few studies compared male versus female cells or animals. Disclosure of sex and comparative studies contribute to our understanding of the biologic basis of sex differences. Addressing sex-specific differences in preclinical research informs subsequent clinical trial design and promotes individualized therapy.Journal of Investigative Dermatology advance online publication, 20 August 2015; doi:10.1038/jid.2015.298.
AB - Given the recent National Institutes of Health proposal for balanced use of male and female cells and animals in preclinical studies, we explored whether sex bias exists in skin research. We surveyed 802 dermatological research articles from 2012 to 2013. No information about the sex of studied cells or animals was provided in 60% of papers. Among keratinocytes of known sex, 70% were male. Few studies compared male versus female cells or animals. Disclosure of sex and comparative studies contribute to our understanding of the biologic basis of sex differences. Addressing sex-specific differences in preclinical research informs subsequent clinical trial design and promotes individualized therapy.Journal of Investigative Dermatology advance online publication, 20 August 2015; doi:10.1038/jid.2015.298.
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U2 - 10.1038/jid.2015.298
DO - 10.1038/jid.2015.298
M3 - Article
SN - 0022-202X
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
ER -