Mind the gap: Sex bias in basic skin research

Betty Y. Kong; Isabel M. Haugh; Bethanee J. Schlosser; Spiro Getsios; Amy S. Paller

doi:10.1038/JID.2015.298

Mind the gap: Sex bias in basic skin research

Betty Y. Kong, Isabel M. Haugh, Bethanee J. Schlosser, Spiro Getsios, Amy S. Paller^*

^*Corresponding author for this work

Dermatology

Research output: Contribution to journal › Short survey › peer-review

26 Scopus citations

Abstract

Given the recent National Institutes of Health proposal for balanced use of male and female cells and animals in preclinical studies, we explored whether sex bias exists in skin research. We surveyed 802 dermatological research articles from 2012 through 2013. No information about the sex of studied cells or animals was provided in 60% of papers. Among keratinocytes of known sex, 70% were male. Few studies compared male versus female cells or animals. Disclosure of sex and comparative studies contribute to our understanding of the biologic basis of sex differences. Addressing sex-specific differences in preclinical research informs subsequent clinical trial design and promotes individualized therapy.

Original language	English (US)
Pages (from-to)	12-14
Number of pages	3
Journal	Journal of Investigative Dermatology
Volume	136
Issue number	1
DOIs	https://doi.org/10.1038/JID.2015.298
State	Published - Jan 2016

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Dermatology
Cell Biology

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10.1038/JID.2015.298

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title = "Mind the gap: Sex bias in basic skin research",

abstract = "Given the recent National Institutes of Health proposal for balanced use of male and female cells and animals in preclinical studies, we explored whether sex bias exists in skin research. We surveyed 802 dermatological research articles from 2012 through 2013. No information about the sex of studied cells or animals was provided in 60% of papers. Among keratinocytes of known sex, 70% were male. Few studies compared male versus female cells or animals. Disclosure of sex and comparative studies contribute to our understanding of the biologic basis of sex differences. Addressing sex-specific differences in preclinical research informs subsequent clinical trial design and promotes individualized therapy.",

author = "Kong, {Betty Y.} and Haugh, {Isabel M.} and Schlosser, {Bethanee J.} and Spiro Getsios and Paller, {Amy S.}",

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AU - Schlosser, Bethanee J.

AU - Getsios, Spiro

AU - Paller, Amy S.

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N2 - Given the recent National Institutes of Health proposal for balanced use of male and female cells and animals in preclinical studies, we explored whether sex bias exists in skin research. We surveyed 802 dermatological research articles from 2012 through 2013. No information about the sex of studied cells or animals was provided in 60% of papers. Among keratinocytes of known sex, 70% were male. Few studies compared male versus female cells or animals. Disclosure of sex and comparative studies contribute to our understanding of the biologic basis of sex differences. Addressing sex-specific differences in preclinical research informs subsequent clinical trial design and promotes individualized therapy.

AB - Given the recent National Institutes of Health proposal for balanced use of male and female cells and animals in preclinical studies, we explored whether sex bias exists in skin research. We surveyed 802 dermatological research articles from 2012 through 2013. No information about the sex of studied cells or animals was provided in 60% of papers. Among keratinocytes of known sex, 70% were male. Few studies compared male versus female cells or animals. Disclosure of sex and comparative studies contribute to our understanding of the biologic basis of sex differences. Addressing sex-specific differences in preclinical research informs subsequent clinical trial design and promotes individualized therapy.

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Mind the gap: Sex bias in basic skin research

Abstract

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