TY - JOUR
T1 - Mindfulness-based stress reduction for HIV treatment side effects
T2 - A randomized, wait-list controlled trial
AU - Duncan, Larissa G.
AU - Moskowitz, Judith Tedlie
AU - Neilands, Torsten B.
AU - Dilworth, Samantha E.
AU - Hecht, Frederick M.
AU - Johnson, Mallory O.
N1 - Funding Information:
This study was funded by grant R21 AT003102 from the National Center for Complementary and Alternative Medicine of the National Institutes of Health . The first author’s role in preparing this article was supported by National Institutes of Health grant NCCAM K01 AT005270 . The authors declare no conflicts of interest.
PY - 2012/2
Y1 - 2012/2
N2 - Context: Advances in antiretroviral therapy (ART) for HIV offer life-extending benefit; however, the side effects associated with ART use negatively impact quality of life and medication adherence among people living with HIV. Objectives: This study tested the efficacy of Mindfulness-Based Stress Reduction (MBSR) for reducing ART symptoms and bother/distress related to ART side effects. Secondary aims were to test the impact of MBSR on medication adherence and psychological functioning. Methods: Seventy-six people living with HIV who were actively taking ART and reported distress from ART-related side effects were randomly assigned to an MBSR program or a wait-list control (WLC) standard care condition. We measured side effects, ART adherence, perceived stress, depression, positive and negative affect, and mindfulness at three time points: baseline, three-month follow-up, and six-month follow-up. Side effects and related distress were assessed separately from other symptoms. Results: Compared with a WLC, participants in the MBSR condition experienced a reduction in the frequency of symptoms attributable to ARTs at three months post-intervention (mean difference = 0.33; 95% confidence interval [CI] = 0.01, 0.66; t(132) = 2.04, P = 0.044) and six months post-intervention (mean difference = 0.38; 95% CI = 0.05, 0.71; t(132) = 2.27, P = 0.025). MBSR participants also experienced a reduction in distress associated with those symptoms at three months post-intervention (mean difference = 0.47; 95% CI = 0.003, 0.94; t(132) = 1.99, P = 0.048) compared with the WLC condition. Conclusion: MBSR is a promising approach for reducing HIV treatment-related side effects.
AB - Context: Advances in antiretroviral therapy (ART) for HIV offer life-extending benefit; however, the side effects associated with ART use negatively impact quality of life and medication adherence among people living with HIV. Objectives: This study tested the efficacy of Mindfulness-Based Stress Reduction (MBSR) for reducing ART symptoms and bother/distress related to ART side effects. Secondary aims were to test the impact of MBSR on medication adherence and psychological functioning. Methods: Seventy-six people living with HIV who were actively taking ART and reported distress from ART-related side effects were randomly assigned to an MBSR program or a wait-list control (WLC) standard care condition. We measured side effects, ART adherence, perceived stress, depression, positive and negative affect, and mindfulness at three time points: baseline, three-month follow-up, and six-month follow-up. Side effects and related distress were assessed separately from other symptoms. Results: Compared with a WLC, participants in the MBSR condition experienced a reduction in the frequency of symptoms attributable to ARTs at three months post-intervention (mean difference = 0.33; 95% confidence interval [CI] = 0.01, 0.66; t(132) = 2.04, P = 0.044) and six months post-intervention (mean difference = 0.38; 95% CI = 0.05, 0.71; t(132) = 2.27, P = 0.025). MBSR participants also experienced a reduction in distress associated with those symptoms at three months post-intervention (mean difference = 0.47; 95% CI = 0.003, 0.94; t(132) = 1.99, P = 0.048) compared with the WLC condition. Conclusion: MBSR is a promising approach for reducing HIV treatment-related side effects.
KW - HIV
KW - Mindfulness-Based Stress Reduction
KW - adherence
KW - antiretroviral therapy
KW - side effects
KW - symptoms
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U2 - 10.1016/j.jpainsymman.2011.04.007
DO - 10.1016/j.jpainsymman.2011.04.007
M3 - Article
C2 - 21925831
AN - SCOPUS:84855897855
SN - 0885-3924
VL - 43
SP - 161
EP - 171
JO - Journal of Pain and Symptom Management
JF - Journal of Pain and Symptom Management
IS - 2
ER -
