Mindfulness-based stress reduction for HIV treatment side effects: A randomized, wait-list controlled trial

Larissa G. Duncan; Judith Tedlie Moskowitz; Torsten B. Neilands; Samantha E. Dilworth; Frederick M. Hecht; Mallory O. Johnson

doi:10.1016/j.jpainsymman.2011.04.007

Mindfulness-based stress reduction for HIV treatment side effects: A randomized, wait-list controlled trial

Larissa G. Duncan, Judith Tedlie Moskowitz, Torsten B. Neilands, Samantha E. Dilworth, Frederick M. Hecht, Mallory O. Johnson^*

^*Corresponding author for this work

Medical Social Sciences

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

Context: Advances in antiretroviral therapy (ART) for HIV offer life-extending benefit; however, the side effects associated with ART use negatively impact quality of life and medication adherence among people living with HIV. Objectives: This study tested the efficacy of Mindfulness-Based Stress Reduction (MBSR) for reducing ART symptoms and bother/distress related to ART side effects. Secondary aims were to test the impact of MBSR on medication adherence and psychological functioning. Methods: Seventy-six people living with HIV who were actively taking ART and reported distress from ART-related side effects were randomly assigned to an MBSR program or a wait-list control (WLC) standard care condition. We measured side effects, ART adherence, perceived stress, depression, positive and negative affect, and mindfulness at three time points: baseline, three-month follow-up, and six-month follow-up. Side effects and related distress were assessed separately from other symptoms. Results: Compared with a WLC, participants in the MBSR condition experienced a reduction in the frequency of symptoms attributable to ARTs at three months post-intervention (mean difference = 0.33; 95% confidence interval [CI] = 0.01, 0.66; t(132) = 2.04, P = 0.044) and six months post-intervention (mean difference = 0.38; 95% CI = 0.05, 0.71; t(132) = 2.27, P = 0.025). MBSR participants also experienced a reduction in distress associated with those symptoms at three months post-intervention (mean difference = 0.47; 95% CI = 0.003, 0.94; t(132) = 1.99, P = 0.048) compared with the WLC condition. Conclusion: MBSR is a promising approach for reducing HIV treatment-related side effects.

Original language	English (US)
Pages (from-to)	161-171
Number of pages	11
Journal	Journal of Pain and Symptom Management
Volume	43
Issue number	2
DOIs	https://doi.org/10.1016/j.jpainsymman.2011.04.007
State	Published - Feb 2012

Funding

This study was funded by grant R21 AT003102 from the National Center for Complementary and Alternative Medicine of the National Institutes of Health . The first author’s role in preparing this article was supported by National Institutes of Health grant NCCAM K01 AT005270 . The authors declare no conflicts of interest.

Keywords

HIV
Mindfulness-Based Stress Reduction
adherence
antiretroviral therapy
side effects
symptoms

ASJC Scopus subject areas

Clinical Neurology
Anesthesiology and Pain Medicine
General Nursing

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jpainsymman.2011.04.007

Cite this

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title = "Mindfulness-based stress reduction for HIV treatment side effects: A randomized, wait-list controlled trial",

abstract = "Context: Advances in antiretroviral therapy (ART) for HIV offer life-extending benefit; however, the side effects associated with ART use negatively impact quality of life and medication adherence among people living with HIV. Objectives: This study tested the efficacy of Mindfulness-Based Stress Reduction (MBSR) for reducing ART symptoms and bother/distress related to ART side effects. Secondary aims were to test the impact of MBSR on medication adherence and psychological functioning. Methods: Seventy-six people living with HIV who were actively taking ART and reported distress from ART-related side effects were randomly assigned to an MBSR program or a wait-list control (WLC) standard care condition. We measured side effects, ART adherence, perceived stress, depression, positive and negative affect, and mindfulness at three time points: baseline, three-month follow-up, and six-month follow-up. Side effects and related distress were assessed separately from other symptoms. Results: Compared with a WLC, participants in the MBSR condition experienced a reduction in the frequency of symptoms attributable to ARTs at three months post-intervention (mean difference = 0.33; 95% confidence interval [CI] = 0.01, 0.66; t(132) = 2.04, P = 0.044) and six months post-intervention (mean difference = 0.38; 95% CI = 0.05, 0.71; t(132) = 2.27, P = 0.025). MBSR participants also experienced a reduction in distress associated with those symptoms at three months post-intervention (mean difference = 0.47; 95% CI = 0.003, 0.94; t(132) = 1.99, P = 0.048) compared with the WLC condition. Conclusion: MBSR is a promising approach for reducing HIV treatment-related side effects.",

keywords = "HIV, Mindfulness-Based Stress Reduction, adherence, antiretroviral therapy, side effects, symptoms",

author = "Duncan, {Larissa G.} and Moskowitz, {Judith Tedlie} and Neilands, {Torsten B.} and Dilworth, {Samantha E.} and Hecht, {Frederick M.} and Johnson, {Mallory O.}",

note = "Funding Information: This study was funded by grant R21 AT003102 from the National Center for Complementary and Alternative Medicine of the National Institutes of Health . The first author{\textquoteright}s role in preparing this article was supported by National Institutes of Health grant NCCAM K01 AT005270 . The authors declare no conflicts of interest. ",

year = "2012",

month = feb,

doi = "10.1016/j.jpainsymman.2011.04.007",

language = "English (US)",

volume = "43",

pages = "161--171",

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T1 - Mindfulness-based stress reduction for HIV treatment side effects

T2 - A randomized, wait-list controlled trial

AU - Duncan, Larissa G.

AU - Moskowitz, Judith Tedlie

AU - Neilands, Torsten B.

AU - Dilworth, Samantha E.

AU - Hecht, Frederick M.

AU - Johnson, Mallory O.

N1 - Funding Information: This study was funded by grant R21 AT003102 from the National Center for Complementary and Alternative Medicine of the National Institutes of Health . The first author’s role in preparing this article was supported by National Institutes of Health grant NCCAM K01 AT005270 . The authors declare no conflicts of interest.

PY - 2012/2

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N2 - Context: Advances in antiretroviral therapy (ART) for HIV offer life-extending benefit; however, the side effects associated with ART use negatively impact quality of life and medication adherence among people living with HIV. Objectives: This study tested the efficacy of Mindfulness-Based Stress Reduction (MBSR) for reducing ART symptoms and bother/distress related to ART side effects. Secondary aims were to test the impact of MBSR on medication adherence and psychological functioning. Methods: Seventy-six people living with HIV who were actively taking ART and reported distress from ART-related side effects were randomly assigned to an MBSR program or a wait-list control (WLC) standard care condition. We measured side effects, ART adherence, perceived stress, depression, positive and negative affect, and mindfulness at three time points: baseline, three-month follow-up, and six-month follow-up. Side effects and related distress were assessed separately from other symptoms. Results: Compared with a WLC, participants in the MBSR condition experienced a reduction in the frequency of symptoms attributable to ARTs at three months post-intervention (mean difference = 0.33; 95% confidence interval [CI] = 0.01, 0.66; t(132) = 2.04, P = 0.044) and six months post-intervention (mean difference = 0.38; 95% CI = 0.05, 0.71; t(132) = 2.27, P = 0.025). MBSR participants also experienced a reduction in distress associated with those symptoms at three months post-intervention (mean difference = 0.47; 95% CI = 0.003, 0.94; t(132) = 1.99, P = 0.048) compared with the WLC condition. Conclusion: MBSR is a promising approach for reducing HIV treatment-related side effects.

AB - Context: Advances in antiretroviral therapy (ART) for HIV offer life-extending benefit; however, the side effects associated with ART use negatively impact quality of life and medication adherence among people living with HIV. Objectives: This study tested the efficacy of Mindfulness-Based Stress Reduction (MBSR) for reducing ART symptoms and bother/distress related to ART side effects. Secondary aims were to test the impact of MBSR on medication adherence and psychological functioning. Methods: Seventy-six people living with HIV who were actively taking ART and reported distress from ART-related side effects were randomly assigned to an MBSR program or a wait-list control (WLC) standard care condition. We measured side effects, ART adherence, perceived stress, depression, positive and negative affect, and mindfulness at three time points: baseline, three-month follow-up, and six-month follow-up. Side effects and related distress were assessed separately from other symptoms. Results: Compared with a WLC, participants in the MBSR condition experienced a reduction in the frequency of symptoms attributable to ARTs at three months post-intervention (mean difference = 0.33; 95% confidence interval [CI] = 0.01, 0.66; t(132) = 2.04, P = 0.044) and six months post-intervention (mean difference = 0.38; 95% CI = 0.05, 0.71; t(132) = 2.27, P = 0.025). MBSR participants also experienced a reduction in distress associated with those symptoms at three months post-intervention (mean difference = 0.47; 95% CI = 0.003, 0.94; t(132) = 1.99, P = 0.048) compared with the WLC condition. Conclusion: MBSR is a promising approach for reducing HIV treatment-related side effects.

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Mindfulness-based stress reduction for HIV treatment side effects: A randomized, wait-list controlled trial

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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