Mineralocorticoid receptors in the mammalian olfactory mucosa

Alan M. Robinson, Robert C. Kern, James D. Foster, Zygmunt S. Krozowski, Dimitri Z. Pitovski*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Mineralocorticoid hormones regulate secretion and absorption in a wide variety of epithelial tissues, although specific mechanisms in the olfactory mucosa are currently unknown. Utilizing reverse transcription-polymerase chain reaction (RT-PCR) analysis, we have demonstrated the expression of mineralocorticoid (type I) receptor messenger RNA in the rodent olfactory mucosa. Amplification products of predicted size were obtained with nucleotide sequences corresponding to respective mineralocorticoid receptor (MR.) kidney transcripts. Immunocytochemistry, using an antibody with known specificity for MRs, was then utilized in order to localize the cellular site(s) of MR protein expression in the olfactory mucosa. The highest levels of MR immunoreactivity were localized to the supranuclear region of sustentacular cells, as well as the acinar cells of the Bowman's glands. The respiratory regions of the nasal cavity were devoid of appreciable MR immunoreactivity. This study demonstrates both MR transcript and protein expression in the olfactory mucosa. We hypothesize that the mineralocorticoid hormones may have a role in modulation of olfactory secretion and/or sensory transduction in the peripheral olfactory system.

Original languageEnglish (US)
Pages (from-to)974-981
Number of pages8
JournalAnnals of Otology, Rhinology and Laryngology
Issue number10
StatePublished - 1999


  • Aldosterone
  • Corticosteroids
  • K-ATPase
  • Na
  • Neurons
  • Olfactory mucus
  • Olfactory receptor cells
  • Sustentacular cells

ASJC Scopus subject areas

  • Otorhinolaryngology


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