Abstract
Development of unconventional technologies for wireless collection and analysis of quantitative, clinically relevant information on physiological status is of growing interest. Soft, biocompatible systems are widely regarded as important because they facilitate mounting on external (e.g., skin) and internal (e.g., heart and brain) surfaces of the body. Ultraminiaturized, lightweight, and battery-free devices have the potential to establish complementary options in biointegration, where chronic interfaces (i.e., months) are possible on hard surfaces such as the fingernails and the teeth, with negligible risk for irritation or discomfort. Here, the authors report materials and device concepts for flexible platforms that incorporate advanced optoelectronic functionality for applications in wireless capture and transmission of photoplethysmograms, including quantitative information on blood oxygenation, heart rate, and heart rate variability. Specifically, reflectance pulse oximetry in conjunction with near-field communication capabilities enables operation in thin, miniaturized flexible devices. Studies of the material aspects associated with the body interface, together with investigations of the radio frequency characteristics, the optoelectronic data acquisition approaches, and the analysis methods capture all of the relevant engineering considerations. Demonstrations of operation on various locations of the body and quantitative comparisons to clinical gold standards establish the versatility and the measurement accuracy of these systems, respectively.
Original language | English (US) |
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Article number | 1604373 |
Journal | Advanced Functional Materials |
Volume | 27 |
Issue number | 1 |
DOIs | |
State | Published - Jan 5 2017 |
Funding
J.K. and P.G. contributed equally to this work. This work was supported by funding from the Simpson Querrey Institute (SQI) Center for Bio-Integrated Electronics, and used facilities in the Frederick Seitz Materials Research Laboratory and the Center for Microanalysis of Materials at the University of Illinois at Urbana-Champaign. Z.X. and X.F. acknowledge the support from the National Basic Research Program of China (Grant No. 2015CB351900) and National Natural Science Foundation of China (Grant Nos. 11402134 and 11320101001). Y.H. acknowledges the support from National Science Foundation (Grant Nos. DMR-1121262, CMMI-1300846, CMMI-1400169, and 1534120) and the National Institutes of Health (Grant No. R01EB019337).
Keywords
- NFC
- flexible electronics
- oximetry
- photonics
- wireless
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- General Chemistry
- Biomaterials
- General Materials Science
- Condensed Matter Physics
- Electrochemistry